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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 10
Issue Published : 108
Article Submitted : 14947
Article Published : 6711
Total Authors : 17943
Total Reviewer : 656
Total Countries : 120
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| Paper Title: | Formulation and Evaluation of Curcumin loaded Solid lipid Nanoparticles by employing Cutina® HR and Carbopol 934 |
| Authors Name: | SHRUTI MADDERLA , P.TRIPURA SUNDARI |
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| Author Reg. ID: |
IJRTI_180639
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| Published Paper Id: | IJRTI1812015 |
| Published In: | Volume 3 Issue 12, December-2018 |
| DOI: | |
| Abstract: | Curcumin was naturally occurring agent with poor solubility also with a bioavailability of 3%. It is useful in many potential pharmacological effects including anti-inflammatory, antibacterial, antioxidant and anticancer activities. It was also proved against cardiovascular disease, Alzheimer’s disease, liver problems, rheumatic arthritis, diabetics, Parkinson’s disease and neurological disorders. To enhance its solubility, permeability and bioavailability nanoparticle technology is very much useful. In the present work attempts were made to prepare the SLNs of curcumin by employing Cutina® HR as solid lipid, Carbopol 934 and soya lecithin as hydrophilic and lipophilic surfactants respectively. The five prepared formulations were evaluated for various parameters like drug content, entrapment efficiency, In Vitro drug release, particle size, Zeta potential, SEM analysis and Stability studies. Among all the Preparations C4 formulation was best in terms of Drug content of 83.1%, Entrapment efficiency of 67.2%, Drug release of 66.1%, Particle size of 796 nm with Zeta potential of -29.4 mV and was also in accordance with particle size in nano range by SEM analysis. The present study conclusively demonstrated that the solubility of drug was improved by entrapment of drug into solid lipid carrier which led to prolongation of drug release. |
| Keywords: | Solid Lipid Nanoparticles, Curcumin, Cutina® HR. |
| Cite Article: | "Formulation and Evaluation of Curcumin loaded Solid lipid Nanoparticles by employing Cutina® HR and Carbopol 934", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.3, Issue 12, page no.81 - 89, December-2018, Available :http://www.ijrti.org/papers/IJRTI1812015.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI1812015
Registration ID:180639
Published In: Volume 3 Issue 12, December-2018
DOI (Digital Object Identifier):
Page No: 81 - 89 Country: HYDERABAD, TELANGANA, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI1812015 Published Paper PDF: https://www.ijrti.org/papers/IJRTI1812015 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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