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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 10
Issue Published : 108
Article Submitted : 14992
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| Paper Title: | ETHNO-PHARMACOLOGY AND NEPHROPROTECTIVE ACTIVITY OF: PINUS STROBUS AND ARAUCARIA HETEROPHYLLA EXTRACTS -ON GENTAMICIN INDUCED NEPHROTOXICITY IN RAT MODELS |
| Authors Name: | Nahid Fatima , Dr. Syed Ahmed Hussain , Rabia Fatima , Amatur rasheed yashfeen |
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IJRTI_181630
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| Published Paper Id: | IJRTI2110006 |
| Published In: | Volume 6 Issue 10, October-2021 |
| DOI: | |
| Abstract: | In the following research study, Pinus strobus and Araucaria heterophylla extracts shown their nephroprotective impact on geneticin-induced nephrotoxicity. Phytochemical analysis was also performed and plants were founf to be rih in alkaloids, terpenes, phenolic compounds. Pinus strobus was found to have thunbergol, 3-carene, cembrene, α-pinene, quercetin, xanthone, Vit C (needles). Whereas, araucaria heterophylla was confirmed for the presence of labda-8, dominated by 13-epi-dolabradiene(42.7%), beyerene (22.2%), rimuene (13.7%), rich in bioflavonoid In all groups, the effects of nephroprotective activity were contextual. During the examination both moderate tubular dilatation and degenerative alterations and tubular edoema were detected. Due to large doses (400mg/kg), Groups 5 Pinu srobus and 7 Araucaria heterophylla had greater therapeutic effect. The nephroprotective effect level was deemed adequate both for safety and for efficacy in sample groups (Group 3 - Group 8), because Group 3 is standardized market formulation and Group 8 is modest combination dose of both plant combinations. The findings indicate that detailed extracts for the experimentally introduced of Pinus strobus and Araucaria heterophyll may be used to decrease the need for conventional nephroprotective therapies such as nephroprotective drugs to maintain your salt, sodium and water systems. The effectiveness and practicality of this combination to help your kidneys release more salt to your urine have been shown in a pre-clinical study utilizing a lower dose for assessments of Pinus strobus and Araucaria heterophylla extracts. |
| Keywords: | Nephroprotectives, Araucaria heterophyll, Pinus strobus, Gentamicin. |
| Cite Article: | "ETHNO-PHARMACOLOGY AND NEPHROPROTECTIVE ACTIVITY OF: PINUS STROBUS AND ARAUCARIA HETEROPHYLLA EXTRACTS -ON GENTAMICIN INDUCED NEPHROTOXICITY IN RAT MODELS", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.6, Issue 10, page no.49 - 64, October-2021, Available :http://www.ijrti.org/papers/IJRTI2110006.pdf |
| Downloads: | 000204827 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
| Publication Details: |
Published Paper ID: IJRTI2110006
Registration ID:181630
Published In: Volume 6 Issue 10, October-2021
DOI (Digital Object Identifier):
Page No: 49 - 64 Country: HYDERABAD, TELENGANA, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2110006 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2110006 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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