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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | COMPREHENSIVE ASSESSMENT OF THE MODE OF DNA BINDING BY FEW ANTICANCER DRUGS |
| Authors Name: | Veenu Gupta , Sourabh Gupta |
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IJRTI_182058
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| Published Paper Id: | IJRTI2205101 |
| Published In: | Volume 7 Issue 5, June-2022 |
| DOI: | |
| Abstract: | either reversible binding or covalent bond formation. The effect of the drugs on transcription factor interactions with DNA is reviewed. These effects can be classified as (i) competition between a drug and regulatory protein for target sequences; (ii) weakening of this interaction; (iii) enhancement of this interaction by chemical modification of the DNA and the creation of non-natural binding sites; and (iv) a ‘suicide’ mechanism, which is observed when a transcription factor induces changes in DNA structure, allowing a drug to bind to a target sequence. Several new strategies – the antigene approach with oligonucleotides, peptide nucleic acids or locked nucleic acids, and sequence-specific polyamides – are also reviewed. Most anticancer drugs affect nucleic acid synthesis, structure or function in cells. As pointed out by Kohn et al.,with few exceptions, they exhibit at least one of the following interactions with DNA: (i) covalent modification, (ii) blocking or poisoning of a DNA topoisomerase (DNA breakage), (iii) inhibition of DNA and/or RNA polymerases, (iv) mimicking nucleic acid precursors, (v) decreasing the precursor concentration, or (vi) blocking the mitotic spindle. Other DNA-related activities relevant to the mechanisms of anticancer drug actions have also been proposed or identified. These include altering the acetylation state of histones and transcription factors, affecting the actions of DNA helicase, or altering DNA–transcription factor interactions, targeting telomerase and DNA structures like G-quadruples in telomeric DNA and the AT islands that probably function as matrix attachment. There are also anticancer drugs which affect transcription processes less directly by inhibition of protein kinases, growth factors or proteasome function, in the latter case sparing proteins which inactivate transcription factors. These multiple mechanisms of action are in principle related to drug structure and its effective concentration, and may result in either a cytotoxic effect or an inhibition of cellular proliferation and induction of cell differentiation. The authors review the existing anticancer drugs for which there are experimental data demonstrating that they affect the interactions of transcription factors with their target sequences in DNA. The authors also outline approaches for the design of new compounds with sufficient selectivity to compete with DNA-dependent RNA polymerase and other elements of the transcriptional machinery, and new strategies which are targeted to a specific interaction with the transcription process or transcriptional regulation. These strategies focus on either the ability of transcription factors to interact with DNA, or engage in protein–protein interactions in transcript some structure. Anticancer drugs like tamoxifen, which are targeted to nuclear receptors (i.e., ligand-dependent specific transcription factors), also remain outside the scope of this review. |
| Keywords: | Daunomycin, Amsa and Acridine-4-carboxamide. |
| Cite Article: | "COMPREHENSIVE ASSESSMENT OF THE MODE OF DNA BINDING BY FEW ANTICANCER DRUGS", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 5, page no.598 - 605, June-2022, Available :http://www.ijrti.org/papers/IJRTI2205101.pdf |
| Downloads: | 000205195 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2205101
Registration ID:182058
Published In: Volume 7 Issue 5, June-2022
DOI (Digital Object Identifier):
Page No: 598 - 605 Country: Akhnoor, Jammu and Kashmir, India Research Area: Chemistry Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2205101 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2205101 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
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