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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 11
Issue Published : 118
Article Submitted : 21545
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| Paper Title: | Evaluation of antidiabetic activity of leaves of convolvulus pluricaulis by enzyme inhibition activity |
| Authors Name: | Shaik Rafiya , K vasantha laxmi , MD Akram , P Sravani , B Rajini |
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IJRTI_183522
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| Published Paper Id: | IJRTI2208154 |
| Published In: | Volume 7 Issue 8, August-2022 |
| DOI: | |
| Abstract: | To investigate the therapeutic effects of Ethanolic leaf extract and its fractions of Convolvulus pluriacualis were evaluated for their on alpha-amylase and alpha-glucosidase inhibition by using in vitro assay. Methods: Leaves of Convolvulus pluriacualis extracted with ethanol and its fractions are prepared by Ethanolic extract of Convolvulus pluriacualis was dispersed in 1L of distilled water separately and was fractionated with toluene, ethyl acetate and butan-2-one in succession. The solvents were removed from the fractions under reduced pressure to yield the corresponding extracts are concentrated under reduced pressure. The inhibitory effect of these extracts on α-amylase and α-glucosidase inhibitory activities as well as some antioxidant parameters was determined in vitro. Results: The results revealed that these ethanolic extracts and its fractions inhibited α-amylase and α-glucosidase activities in a dose dependent manner. The plant extracts and their fractions were used at varying concentrations to ensure which concentration of the extract and its fractions causes the most inhibition. Among all fractions, Ethyl acetate fraction of Convolvulus pluriacaulis has shown the prominent enzyme inhibitory activity (for α-amylase and α-glucosidase inhibitory activities with IC50 values of 4.95 mg/ml and 4.4 mg/ml) as well as comparable with standard drug acarbose (for α-amylase IC50 2.32 mg/ml and for α-glucosidase IC50 2.00mg/ml) respectively. Phytochemical analysis of the extracts indicated the presence of Alkaloids,flavonoids, steroids/triterpenoids and their glycosides, saponins, phenolic compounds. Further, the total phenolic and total flavonoid contents were estimated. These results substantiate the use of Convolvulus pluricaulis in traditional medicine for the treatment of diabetes by controlling postprandial hyperglycemia. Conclusion: The antioxidant properties and enzyme inhibition could be part of the mechanism by which they are used in the treatment/prevention of type-2 diabetes. These findings suggest that the plants may be a potential source for the development of new oral hypoglycemic agent |
| Keywords: | Convolvulus pluricaulis, α-amylase, α-glucosidase, Acarbose, Total flavonoids, Total phenolics. |
| Cite Article: | "Evaluation of antidiabetic activity of leaves of convolvulus pluricaulis by enzyme inhibition activity", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 8, page no.894 - 898, August-2022, Available :http://www.ijrti.org/papers/IJRTI2208154.pdf |
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| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2208154
Registration ID:183522
Published In: Volume 7 Issue 8, August-2022
DOI (Digital Object Identifier):
Page No: 894 - 898 Country: Suryapet, Telangana, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2208154 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2208154 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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