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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14

Issue per Year : 12

Volume Published : 7

Issue Published : 79

Article Submitted : 5529

Article Published : 3056

Total Authors : 7817

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Paper Title: Spectrophotometric method for the determination of dorzolamide in bulk drug and pharmaceutical dosage form
Authors Name: P.Pravalika , Namami dutt , Kamsu likhita
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IJRTI_183704
Published Paper Id: IJRTI2208191
Published In: Volume 7 Issue 8, August-2022
DOI:
Abstract: In present work a simple, precise, accurate UV spectrophotometric method has been developed for determination of Dorzolamide in bulk drug and its pharmaceutical formulations. Dorzolamide was found to exhibit maximum absorbance at 255nm with methanol as solvent. The present method was validated as per guidelines of the International Conference on Harmonization (ICH) including parameters like linearity, accuracy, precision, limit of detection and limit of quantification. Drug obeyed Beer’s law in concentration range of 10-50 µg/mL and the linear regression equation was Y= 0.01008 x+0.0172. The percentage recovery of Dorzolamide was found to be 98.3-100.13. The precision was evaluated and % relative standard deviation (RSD) was less than 2%, LOD was found to be 2.178µg/mL & LOQ was found to be 6.60µg/mL respectively. The results suggest that this method can be employed for routine analysis of Dorzolamide in bulk drug and its pharmaceutical formulations.
Keywords: Dorzolamide, Methanol, UV spectrophotometry, Validation
Cite Article: "Spectrophotometric method for the determination of dorzolamide in bulk drug and pharmaceutical dosage form ", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 8, page no.1193 - 1197, August-2022, Available :http://www.ijrti.org/papers/IJRTI2208191.pdf
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ISSN: 2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publication Details: Published Paper ID: IJRTI2208191
Registration ID:183704
Published In: Volume 7 Issue 8, August-2022
DOI (Digital Object Identifier):
Page No: 1193 - 1197
Country: medchel, telangana, India
Research Area: Pharmacy
Publisher : IJ Publication
Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2208191
Published Paper PDF: https://www.ijrti.org/papers/IJRTI2208191
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016

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