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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
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Issue Published : 118
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| Paper Title: | Enhancement of Solubility, Dissolution rate and Bioavailability of poorly water soluble drug Pioglitazone using Nanoprecipitation |
| Authors Name: | Miss. Snehal Navalsing Patil , Dr.S.P.Warke , Mrs.R.V.Patil , Dr.P.D.Warke |
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IJRTI_183868
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| Published Paper Id: | IJRTI2208211 |
| Published In: | Volume 7 Issue 8, August-2022 |
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| Abstract: | ABSTRACT The aim of this study was to develop amorphous nanoparticles of poorly aqueous soluble anti diabetic drug, Pioglitazone by high flow antisolvent precipitation technique. The mean particle size was controlled by different parameters like the AS(Anti-solvent)/S(Solvent) ratio, the solvents, the feed drug concentration, the stabilizers, the stabilizer concentration, the stirring speed, time and the organic solvent flow rate. The produced Pioglitazone nanoparticles were characterized by Scanning electron microscopy (SEM), Fourier transform infrared spectrophotometry (FTIR), Powder X-ray diffraction (XRD), particle size and specific surface area analysis, Differential scanning calorimetry (DSC), dissolution test, solubility study. Pioglitazone nanoparticles with a mean size of 220 nm and specific surface area with 51.7 m2/g were successfully prepared. The solubility increased from 0.067 mg/ml to 0.254 mg/ml, which is 4 times increment in drug solubility. In dissolution study, nanoparticles showed 100% drug release within 30 min, while the raw Pioglitazone showed 100% drug release within 120 min. The results suggest that by varying the different formulation parameter achieved nanoparticles with required particle size, high specific surface area, solubility and drug release. |
| Keywords: | Keywords: Nanoparticle, Pioglitazone, Anti-solvent precipitation, Stabilizers, Particle size, Specific surface area. |
| Cite Article: | "Enhancement of Solubility, Dissolution rate and Bioavailability of poorly water soluble drug Pioglitazone using Nanoprecipitation", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 8, page no.1294 - 1309, August-2022, Available :http://www.ijrti.org/papers/IJRTI2208211.pdf |
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| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2208211
Registration ID:183868
Published In: Volume 7 Issue 8, August-2022
DOI (Digital Object Identifier):
Page No: 1294 - 1309 Country: Jalgaon, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2208211 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2208211 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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