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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.14 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)

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Impact Factor : 8.14

Issue per Year : 12

Volume Published : 7

Issue Published : 79

Article Submitted : 5505

Article Published : 3032

Total Authors : 7767

Total Reviewer : 540

Total Countries : 67

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Paper Title: A REVIEW OF PROTECTIVE EFFECT OF EPHRIN RECEPTOR AGONIST DOXAZOSIN IN MYOCARDIAL INJURY
Authors Name: Komal , Kapil Kumar Verma , Panshul Sharma
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IJRTI_183911
Published Paper Id: IJRTI2208261
Published In: Volume 7 Issue 8, August-2022
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Abstract: The biggest family of receptor tyrosine kinases, eph receptors interact with membrane-bound ephrin ligands to regulate a wide range of vital human activities, from embryonic development to adult tissue homeostasis. Eph receptors and ephrin ligands are widely expressed throughout immune system and cardiovascular system, which emphasises how crucial these molecules are for coordinating the best response. The numerous functions of Eph receptors and ephrin ligands. In their interaction with Eph receptors might be a potential therapeutic target in treatment of myocardial infarction are summarised in this study. We also go over the significance of Ephrin-Eph signalling has been shown to reduce inflammation and apoptosis after an ischemic insult and promote angiogenesis. Doxazosin has been reported to activate EphA2 receptors at 25 μM and 50μM. in HEK and PC-3 cells respectively. Oxidative stress generated within first few minutes of myocardial reperfusion has been reported in myocardial injury and cardiomyocyte death through a number of differ mechanisms that PI3/AKt pathway may be involved in cardio protective effect of Doxazosin downstream Ephrin A2 receptor activation. The numerous and important functions investigated of Eph receptors and ephrin ligands throughout the system both when it is dormant and active.
Keywords: Myocardial infarction, Eph receptors, Oxidative stress, Doxazosin, Angiogenesis
Cite Article: "A REVIEW OF PROTECTIVE EFFECT OF EPHRIN RECEPTOR AGONIST DOXAZOSIN IN MYOCARDIAL INJURY", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 8, page no.1637 - 1650, August-2022, Available :http://www.ijrti.org/papers/IJRTI2208261.pdf
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ISSN: 2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publication Details: Published Paper ID: IJRTI2208261
Registration ID:183911
Published In: Volume 7 Issue 8, August-2022
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Page No: 1637 - 1650
Country: -, -, -
Research Area: Engineering
Publisher : IJ Publication
Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2208261
Published Paper PDF: https://www.ijrti.org/papers/IJRTI2208261
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016

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