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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
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Issue Published : 118
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| Paper Title: | Recent developments in oral drug delivery of biologics |
| Authors Name: | P.Shailaja , J.Ramya , Y.Samukhya , G.Sneha Latha |
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IJRTI_184152
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| Published Paper Id: | IJRTI2209112 |
| Published In: | Volume 7 Issue 9, September-2022 |
| DOI: | |
| Abstract: | Oral administration of medications is typically preferred by patients because it is more convenient; however, biologics cannot currently be administered orally, due to its many advantages, such as patient compliance, non-invasiveness, and ease of drug administration, it is often the most advantageous route for physicians. Despite this, the physiological barriers of the gastrointestinal (GI) tract prevent oral biologic delivery from being effectively tested. Multiple barriers in the GI tract prevent complex macromolecules from being absorbed into the systemic circulation after consumption. Mucosal permeability, drug solubility, and environmental stability in the GI tract are some of the factors that affect how well oral medications are absorbed. The GI tract is such a harsh environment, that biologics are extremely susceptible to it. In addition to this problem, biologics comparatively high molecular sizes result in exceedingly low intestinal mucosal permeability. Oral biologics delivery research has a long and rich history and the growth of biologics in recent decades has further accelerated research activity. To improve oral drug absorption, a variety of pharmaceutical technologies and drug delivery systems, such as cyclodextrins, micelles, nano-carriers, and lipid-based carriers, have been investigated. Physiological barriers to oral biologic delivery are outlined in this article, along with various research approaches to enable or enhance oral biologic delivery. The advantages and disadvantages of oral drug delivery methods will also be highlighted, along with the general feasibility and potential of this future clinical field. |
| Keywords: | : Oral drug delivery; absorption enhancers; biologics; gastrointestinal barriers; insulin; microneedle pill; |
| Cite Article: | "Recent developments in oral drug delivery of biologics", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 9, page no.840 - 844, September-2022, Available :http://www.ijrti.org/papers/IJRTI2209112.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2209112
Registration ID:184152
Published In: Volume 7 Issue 9, September-2022
DOI (Digital Object Identifier):
Page No: 840 - 844 Country: Visakhapatnam, ANDHRA PRADESH, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2209112 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2209112 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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