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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | Stability Indicating RP-HPLC Method Development And Validation For Simultaneous Estimation of Atorvastatin, Fenofibrate And Ezetimibe In Pharmaceutical Dosage Form |
| Authors Name: | Yogini A. Thakare , Ms. Janki A. Patel , Dr. Ekta D. Patel , Mr. Ronak N. Patel , Mr. Jaymin G. Patel |
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IJRTI_185693
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| Published Paper Id: | IJRTI2304015 |
| Published In: | Volume 8 Issue 4, April-2023 |
| DOI: | |
| Abstract: | Simple, rapid, economical, precise and accurate Stability indicating RP- HPLC method for the estimation of Atorvastatin, Fenofibrate and Ezetimibe in pharmaceutical Dosage Form has been developed. A reverse phase high performance liquid chromatographic method was developed for the estimation of Atorvastatin, Fenofibrate and Ezetimibe in pharmaceutical Dosage Form has been developed. The separation was achieved Column Kromasil C18 (150 x 4.6) 5 µm ID, Gradient program Acetonitrile and Water as mobile phase, at a flow rate of 1.3 ml/min. Detection was carried out at 234 nm retention time of Ezetimibe, Atorvastatin and Fenofibrate was found to be 6.75, 7.85 and14.80 min. The method has been validated for linearity, accuracy and precision. Linearity observed for Atorvastatin, Fenofibrate and Ezetimibe 4.95-238.56 μg/ml. Developed method was found to be accurate, precise and rapid for estimation of Atorvastatin, Fenofibrate and Ezetimibe in pharmaceutical Dosage Form. The drug was subjected to stress condition of hydrolysis, oxidation, photolysis and Thermal degradation, under same chromatographic condition. The stress samples were assayed on RP-HPLC system. |
| Keywords: | Atorvastatin, Fenofibrate and Ezetimibe, Stability indicating RP- HPLC Method, Validation. |
| Cite Article: | "Stability Indicating RP-HPLC Method Development And Validation For Simultaneous Estimation of Atorvastatin, Fenofibrate And Ezetimibe In Pharmaceutical Dosage Form ", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 4, page no.76 - 89, April-2023, Available :http://www.ijrti.org/papers/IJRTI2304015.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2304015
Registration ID:185693
Published In: Volume 8 Issue 4, April-2023
DOI (Digital Object Identifier):
Page No: 76 - 89 Country: Ahmedabad, Gujarat, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2304015 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2304015 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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