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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | Formulation Development and Evaluation of Dispersible Levosalbutamol Tablet |
| Authors Name: | Md Mainuddin Ahmed Shah , Mr. Manmohan Sharma , Mr.Anil Sharma , Mr.Giris Vyas |
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IJRTI_186023
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| Published Paper Id: | IJRTI2304094 |
| Published In: | Volume 8 Issue 4, April-2023 |
| DOI: | |
| Abstract: | It was estimated that more than 339 million people suffer from asthma. Asthma is the most common noncommunicable disease among children. Most deaths occur in older adults. Under Preformulation study, the physicochemical properties were complied with the IP and USP specification. Physical properties such as appearance, melting point, effect of temperature and humidity in different conditions were more in Levosabutamol raw powder. Parameters evaluated were within the USP limit. Asthma symptoms are the result of bronchial hyperresponsiveness, bronchospasm, and chronic airway inflammation. Short-acting, inhaled beta2 agonists; oxygen; intravenous fluids; and corticosteroids are the mainstays of treatment for acute exacerbations. The R-enantiomer of albuterol is responsible for bronchodilation. The S-enantiomer exhibits broncho-constricting activity in vitro, which may be mediated by muscarinic receptors and may be opposed by adding the anticholinergic agent ipratropium bromide. Levalbuterol improves pulmonary function to a greater extent than racemic albuterol and reduces the need for costly hospitalizations in patients with acute asthma exacerbations. The formulations were evaluated on the basis of Pharmacopoeial specification visual appearance, pH, drug content, Hardness, Friability, Disintegration test, assessment of drug release, release kinetics were carried out as per specifications and results were found to be complied with the Pharmacopoeial specification. The compatibility evaluations were performed by FTIR spectroscopy. The observation implies that the drug and polymers were compatible with each other. There were no interaction found between polymers and drug. |
| Keywords: | Asthma, Levosabutamol, bronchial hyper responsiveness, bronchodilator, Dispersible Tablet |
| Cite Article: | "Formulation Development and Evaluation of Dispersible Levosalbutamol Tablet", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 4, page no.561 - 573, April-2023, Available :http://www.ijrti.org/papers/IJRTI2304094.pdf |
| Downloads: | 000205260 |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2304094
Registration ID:186023
Published In: Volume 8 Issue 4, April-2023
DOI (Digital Object Identifier):
Page No: 561 - 573 Country: Murshidabad, West Bengal, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2304094 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2304094 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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