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Abstract— The objective of the current study was to carefully examine some of the significant physicochemical characteristics of rifaximin for pellet manufacturing. Rifaximin underwent testing for its physicochemical qualities, including solubility, dissolution, melting point, assay development, excipient compatibility, etc. Based on the formed pellets' dissolution characteristics, a binder and disintegrant were selected. Good flow characteristics, excipient compatibility, solubility profile, melting point, entrapment efficiency, and release profile are the results of the preformulation research. We can infer from this work that 2% sodium carboxymethyl cellulose can be used as a binder, and 2.5% sodium starch glycollate can be used as a disintegrant, to create Rifaximin pellets.
"Development of pellets: Preformulation studies and initial screening of excipients", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 6, page no.312 - 317, June-2023, Available :http://www.ijrti.org/papers/IJRTI2306050.pdf
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator