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Background: Medication overuse headache (MOH), formerly known as drug-induced headache, which affects 1% of people worldwide, constitutes one of the most debilitating headache conditions. However, it's entirely different, the use of acute symptomatic medications for 10–15 days in a month (depending on the drug class, such as simple analgesics, triptans, and opioids) and the use of these medications for headache relief for three months or more in patients having a history of primary headache disorders.
Objective: With an emphasis on recent developments in the fields of pathophysiology, risk factors, clinical features, and treatment, the purpose of this article was to examine the subject of MOH and provide the specifics of this condition.
Material and methods: For the purpose of writing this review, a search of the literature was conducted using appropriate keywords in the PubMed/MEDLINE and Springer databases. We reviewed around 71 articles by using keyword like “MOH”, “pathophysiology of MOH”, ”risk factors of MOH”, “CGRP”. Boolean operators “AND" and "OR" were employed.
Results: The idea of MOH has changed over time, despite one occurrence of grey matter disturbances, the distinct pathogenesis is still being contemplated. Modification in pain pathways, changes in areas of the brain associated with pain intensity, and neurotransmitter changes have all been related to genetic vulnerability. A detailed medical history is required to separate it from other secondary recurring daily headache disorders, focused testing, and information on medication usage. The most common forms of treatment for primary headache disorders in outpatient or inpatient settings include patient disease information, abstinence of the causative agent, and management through preventive medications are all approaches.
Conclusions: Any person with a chronic headache should be evaluated for MOH, a secondary headache disease. Its development is linked to a number of pathophysiological pathways and risk factors. Detoxification, preventive therapy, and education on the disorder are all part of management
"Medication Over Use Headache: Characteristic, Etiopathophysiology, Diagnosis and Emerging Treatment", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 7, page no.362 - 370, July-2023, Available :http://www.ijrti.org/papers/IJRTI2307055.pdf
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator