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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | Synthesis and Characterization of Chemotherapeutic Agent Quinolinol Series |
| Authors Name: | Divya Rathore , Mr Reneesh Jaiswal , Mrs Manorama Ratre |
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IJRTI_187882
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| Published Paper Id: | IJRTI2308072 |
| Published In: | Volume 8 Issue 8, August-2023 |
| DOI: | |
| Abstract: | Cancer, which remains an ever-increasing threat to the people’s health worldwide, has become the second most common cause of death nowadays Considerable efforts have been made by a growing number of researchers to design new therapeutic anticancer agents. A new series of N-substituted azetidinones (9a–h) synthesized by condensation of 4-arylidene hydrazine 1-isobutyl-1H-imidazo [4, 5-c] quinolines (8a–h) with chloroacetyl chloride afforded 4-arylazetidin-2-ones (9a–h). The synthesized compounds were characterized by 1H NMR, 13C NMR, mass spectral and elemental analyses. All synthesized compounds were screened for their anticancer activities. Compounds 9a and 9b exhibited good anticancer activity. In a molecular docking study compounds 9a and 9b showed minimum binding energy and good affinity towards the active pocket. Thus, are believed to be good inhibitors of β-tubulin. Although there are several existing methods available, there are no routes that synthesize 4-quinolones in flow. Additionally, most syntheses focus on the carboxylated quinolone, where as the route described in this thesis leads to 3- unsubstituted quinolones. The result is a product that has increased diversity toward the accessibility of target structures, making the chemistry even more valuable. |
| Keywords: | Anticancer activity, hydroxyl quinoline, carboxylated quinolone, |
| Cite Article: | "Synthesis and Characterization of Chemotherapeutic Agent Quinolinol Series", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 8, page no.440 - 446, August-2023, Available :http://www.ijrti.org/papers/IJRTI2308072.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2308072
Registration ID:187882
Published In: Volume 8 Issue 8, August-2023
DOI (Digital Object Identifier):
Page No: 440 - 446 Country: korba , chhattisgarh, India Research Area: Chemistry Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2308072 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2308072 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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