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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 10
Issue Published : 115
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Published Paper Details
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| Paper Title: | Sitagliptin a DPP-4 Inhibitor |
| Authors Name: | Purvita Laxman waghmodey , Mayur Rajkumar Raut , Manorama Namdev Naiknaware |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJRTI_188069
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| Published Paper Id: | IJRTI2309041 |
| Published In: | Volume 8 Issue 9, September-2023 |
| DOI: | https://doi.org/10.56975/ijrti.v8i9.188069 |
| Abstract: | Diabetes mellitus(DM) is a worldwide rising concern that leads to an increased rate of mortality, morbidity and health-care costs. DM is a chronic, endocrine isorder associated with hyperglycemia. The current estimated DM prevalence is over 422 millions and has been progressively increasing over the past decades. Consequently, it is considered a significant problem in health care setting. Health care professional WHO deals with such patients need to have an adequate information and drug therapy management including drug and its regime that are presently available in the market. This review provides an overview of the potential diabetic drugs and their mechanisms. Here, it will be proved beneficial for health care professional. Sitagliptin is a member of the gliptin class of antidiabetic medications. It’s mechanism of action is through inhibition of dipeptidyl peptidase-4(DPP-4),an enzyme that acts to degrade and inactivate glucagon like peptide-1 (GLP-1), DPP-4 is an enzyme that is involved in the rapid metabolism of incretin, such as glucagon like peptide. Sitagliptinspperas to be highly selective for DPP-4 and has 2600 times selectivity for DPP-4 compared with DPP-8 and DPP-9. Sitagliptin under the trade name Januvia was the first agent developed in the class of DPP-4 inhibitors approved by FDA in oct 2006. Sitagliptin exhibit excellent oral bioavailability in preclinical species. |
| Keywords: | Diebetes mellitus , hyperglycemia,FDA. |
| Cite Article: | "Sitagliptin a DPP-4 Inhibitor ", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 9, page no.326 - 336, September-2023, Available :http://www.ijrti.org/papers/IJRTI2309041.pdf |
| Downloads: | 000205298 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
| Publication Details: |
Published Paper ID: IJRTI2309041
Registration ID:188069
Published In: Volume 8 Issue 9, September-2023
DOI (Digital Object Identifier): https://doi.org/10.56975/ijrti.v8i9.188069
Page No: 326 - 336 Country: Sangola, Solapur , Maharashtra , India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2309041 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2309041 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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