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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | Identification of Phytochemical From Ficus carica (Fig) As Inhibitor of Glycosylated Membrane Protein Of Human Adenovirus: An In Silico Approach |
| Authors Name: | Dr. Debdoot Gupta , Riya Saha |
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IJRTI_188121
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| Published Paper Id: | IJRTI2310010 |
| Published In: | Volume 8 Issue 10, October-2023 |
| DOI: | |
| Abstract: | Adenovirus is a group of common virus which causes infection in eyes, air ways, lungs and intestine. It causes infection in all type of age groups. Recently this virus has caused pandemic at 1-12/13 age groups child on Feb 2023 in West-Bengal. Though some drugs have been already designed against adenovirus, their side effects warrant the need for alternative natural therapeutic interventions. Phytochemicals are compounds having plant origin and can be used as therapeutic strategy with no or less side effects than traditional drugs and there is also less chance to develop resistance against these compounds. In this study, bioinformatic pipeline has been developed to identify Phytochemicals from Ficus carica (Fig, Bengali name “Dumur”) phenolic leaf extracts which can inhibit adenoviral glycosylated membrane protein, a protein which has been reported to act as antiviral drug target. For searching of inhibitors against this target protein from Ficus carica (Fig), initially 116 phytochemicals were screened from IMPPAT (Indian Medicinal Plants, Phytochemistry and Therapeutics) database and out of them 94 were passed the ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) properties. Those phytochemicals has been run for molecular docking analysis against the adenoviral 18.5 kDa Glycosylated Membrane protein (18.5 kDa GMP) by Auto dock vina through PyRx. Docking analysis showed that Taraxasterol exhibited most favorable binding affinity (-7.8 kcal/mol) than other compounds as well as than natural ligand of glycosylated membrane protein. So this compound can be used as novel, natural therapeutic agent against Adenoviral target protein. However, further in vitro and in vivo study using this potential adenoviral inhibitor is needed for further validation. |
| Keywords: | Phytochemical, Ficus carica, IMPPAT, ADMET, Glycosylated Membrane protein, PyRx, Taraxasterol. |
| Cite Article: | "Identification of Phytochemical From Ficus carica (Fig) As Inhibitor of Glycosylated Membrane Protein Of Human Adenovirus: An In Silico Approach", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 10, page no.56 - 64, October-2023, Available :http://www.ijrti.org/papers/IJRTI2310010.pdf |
| Downloads: | 000205163 |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
| Publication Details: |
Published Paper ID: IJRTI2310010
Registration ID:188121
Published In: Volume 8 Issue 10, October-2023
DOI (Digital Object Identifier):
Page No: 56 - 64 Country: Burdwan, West-Bengal, India Research Area: Biological Science Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2310010 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2310010 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
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