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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Volume 10 | Issue 12
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 10
Issue Published : 115
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| Paper Title: | Solubility Enhancement Techniques Of Poorly Soluble Drugs With Special Emphasis On Amorphous Solid Dispersion |
| Authors Name: | Miss. Archana Khot , Dr. Sujit Kakade , Dr. Ashok Bhosale |
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IJRTI_202457
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| Published Paper Id: | IJRTI2504145 |
| Published In: | Volume 10 Issue 4, April-2025 |
| DOI: | |
| Abstract: | The solubility of active pharmaceutical ingredients (APIs) plays a critical role in drug development, affecting bioavailability and therapeutic effectiveness. A significant number of new chemical entities (NCEs) exhibit poor water solubility, limiting their absorption and efficacy. This review focuses on various solubility enhancement techniques, with a special emphasis on amorphous solid dispersions (ASDs). ASDs, achieved through solid dispersion technology, enhance drug dissolution rates by preventing recrystallization and maintaining a high-energy amorphous state. The selection of appropriate polymers, such as PVP, HPMC, and Eudragit, is crucial for stabilizing ASDs. Different manufacturing methods, including spray drying, hot-melt extrusion, electro spraying, and supercritical fluid technology, are explored, highlighting their advantages and limitations. The article also discusses the stability challenges of ASDs and characterization techniques such as DSC, XRPD, and FTIR. The advancements in ASDs offer promising solutions for improving drug solubility and bioavailability, contributing to the effective formulation of poorly soluble drugs. |
| Keywords: | Amorphous solid dispersions, Glass transition temperature, Recrystallization, Hot-melt extrusion, Spray drying |
| Cite Article: | "Solubility Enhancement Techniques Of Poorly Soluble Drugs With Special Emphasis On Amorphous Solid Dispersion", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 4, page no.b369-b386, April-2025, Available :http://www.ijrti.org/papers/IJRTI2504145.pdf |
| Downloads: | 000285 |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2504145
Registration ID:202457
Published In: Volume 10 Issue 4, April-2025
DOI (Digital Object Identifier):
Page No: b369-b386 Country: Pune, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2504145 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2504145 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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