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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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Issue Published : 115
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| Paper Title: | Ethosomes as topical drug delivery system |
| Authors Name: | Shrutika Tanaji Harpale , Trusha Shangrapawar , Ashok Bhosle |
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| Author Reg. ID: |
IJRTI_202429
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| Published Paper Id: | IJRTI2504146 |
| Published In: | Volume 10 Issue 4, April-2025 |
| DOI: | |
| Abstract: | Ethosomes are an advanced lipid-based vesicular system designed to enhance the delivery of drugs through the skin. Composed primarily of phospholipids, high concentrations of ethanol (20-45%), and water, ethosomes are known for their deformable and elastic nature, which allows them to penetrate the tough stratum corneum barrier more effectively than traditional liposomes. The ethanol present in ethosomes plays a dual role: it increases the fluidity of the vesicle membrane and disrupts the skin's lipid layers, thereby facilitating deeper penetration of both hydrophilic and lipophilic drugs into the systemic circulation. Ethosomal systems have proven to be effective in improving the bioavailability of drugs, sustaining drug release, reducing systemic side effects, and enhancing patient compliance. These vesicles are utilized for the transdermal delivery of a wide variety of therapeutic agents, including antimicrobial, antifungal, antiviral, anti-inflammatory, and neuroactive drugs, as well as large biomolecules such as peptides and proteins. Ethosomes offer several advantages over conventional transdermal delivery systems, such as non-invasiveness, ease of preparation, and the ability to improve drug permeation across the skin. Due to their promising characteristics, ethosomes hold significant potential in pharmaceutical, cosmetic, and biomedical applications, making them a valuable innovation in topical drug delivery technology. |
| Keywords: | Ethosomes, TDDS, Phospholipids, Ethanol, Skin Permeation, Vesicular System, Hydrophilic Drugs, Lipophilic Drugs, Non-invasive Delivery, Vesicle Stability, Targeted Drug Delivery. |
| Cite Article: | "Ethosomes as topical drug delivery system", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 4, page no.b387-b401, April-2025, Available :http://www.ijrti.org/papers/IJRTI2504146.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2504146
Registration ID:202429
Published In: Volume 10 Issue 4, April-2025
DOI (Digital Object Identifier):
Page No: b387-b401 Country: Pune, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2504146 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2504146 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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