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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 10
Issue Published : 115
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| Paper Title: | The Future of Neurological Research: Advances in Microfluidic Blood Brain Barrier (BBB) Models |
| Authors Name: | Pratiksha Mhalsane , Mrunali Dhakare , Renuka Sutane |
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IJRTI_202204
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| Published Paper Id: | IJRTI2504152 |
| Published In: | Volume 10 Issue 4, April-2025 |
| DOI: | |
| Abstract: | Diseases of the central nervous system (CNS) represent a significant contributor to the global health burden. However, newly licensed medications for these conditions rank among the lowest in comparison to their counterparts. The lack of dependable and effective in vitro blood-brain barrier (BBB) models that accurately mimic in vivo barrier characteristics significantly impedes the advancement of effective therapies for central nervous system (CNS) disorders. The blood-brain barrier (BBB) serves as a natural membrane that safeguards the central nervous system (CNS) against bloodborne toxins and viruses. The presence of the blood-brain barrier complicates pharmacotherapy for central nervous system disorders, as most chemical drugs and biopharmaceuticals cannot penetrate the brain. Insufficient delivery of medication to the brain diminishes therapeutic effectiveness and increases adverse effects due to accumulation in other organs and tissues. Brain physiology and complex medical development processes render brain disorders the most debilitating health issue worldwide, contributing to increasing annual mortality rates. The blood-brain barrier (BBB) and its constituents are essential for safeguarding the brain; however, their intricate nature complicates the delivery of medications to this organ. The BBB is a primary factor in treatment failures, potentially leading to disease progression. Recent advancements in materials science and nanotechnology have resulted in a range of advanced materials with tailored structures and properties, functioning as a valuable resource for targeted drug delivery. A thorough examination of anatomical and pathological studies of the brain and blood-brain barrier supports the creation of targeted approaches to improve permeability across the blood-brain barrier. Thus, it is crucial to identify an optimal platform for predicting the behaviour of a drug delivery system in the brain during the early developmental phase. In the last twenty years, researchers have created and examined multiple in vitro blood-brain barrier models to improve comprehension of barrier properties and the degree to which these models mimic the in vivo blood-brain barrier. In vitro models of the blood-brain barrier primarily consist of endothelial cell cultivation, frequently in co-culture with additional perivascular cells, utilising two- or three-dimensional platforms. This review offers a thorough guideline for researchers in diverse fields, highlighting advancements in brain-targeted drug delivery systems. |
| Keywords: | Microfluidic Blood Brain Barrier (BBB) Model; Blood-Brain Barrier (BBB); Tight Junctions; Endothelial Cells; Stem Cells; Perivascular Cells; Microenvironment; In Vitro Model |
| Cite Article: | "The Future of Neurological Research: Advances in Microfluidic Blood Brain Barrier (BBB) Models", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 4, page no.b441-b457, April-2025, Available :http://www.ijrti.org/papers/IJRTI2504152.pdf |
| Downloads: | 000301 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2504152
Registration ID:202204
Published In: Volume 10 Issue 4, April-2025
DOI (Digital Object Identifier):
Page No: b441-b457 Country: Chikhli, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2504152 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2504152 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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