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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | Design and Development Of Thermo-responsible Nanoparticles Containing Nasal Gel Of Lercanidipine |
| Authors Name: | Umesh Kumar chaurasiya , Abhishek Rai |
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| Author Reg. ID: |
IJRTI_207342
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| Published Paper Id: | IJRTI2511030 |
| Published In: | Volume 10 Issue 11, November-2025 |
| DOI: | |
| Abstract: | Lercanidipine is a vasoselective dihydropyridine calcium antagonist, mainly used for the treatment of hypertension and angina pectoris. However, it suffers from food dependent absorption, poor solubility, low permeability and considerable first pass metabolism, resulting in highly variable and low bioavailability of 10%. In present research work, attempt has made to develop fast dissolving films and theroresponsive nasal gel incorporated with lercanidipine nanoparticles. Nanoparticles of lercanidipine were incorporated in thermoresponsive nasal gel via preparation of nanosuspension by evaporative antisolvent precipitation method. Prepared nanosuspensions were incorporated in formulations without lyophilizing or spray drying. The DSC and XRD results proved the poorly crystalline nature of lercanidipine. However thermal processing of film induces crystallinity in hypromellose which results in embedding of amorphous drug nanoparticles in semicrystalline polymeric matrix. Superior dissolution and permeability properties of nanoparticles were confirmed by in-vitro dissolution studies and about 4.5 folds higher ex vivo drug permeation was observed from formulation through porcine buccal mucosa. Same way nanosuspension of lercanidipine was prepared by using poloxamer and TPGS as nanosuspension stabilizers. Formulated nanosuspension was incorporated in thermo-responsive nasal gelling composition which was made up of 14.5% poloxamer, 1% TPGS and 0.1% chitosan lactate. Thermoresponsible nasal gel containing nanoparticles exhibits gelling temperature at 29ºC. Mucoadhesive strength of gel formulations was determined by texture analyzer. Incorporation of cationic drug increases the mucoadhesive strength of the gel. In situ gel formulation containing lercanidipine nanoparticles showed 6.5 folds higher permeation through goat nasal mucosa compared to plain drug. Nanonization of the drug, trans-mucosal administration of lercanidipine along with formulation considerations resulted into around 2.5 and 1.2 folds increase in the relative bioavailability for nasal and oral-transmucosal formulation respectively over oral administration of lercanidipine. |
| Keywords: | transmucosal, nanoparticles, lercanidipine, poloxamer,Thermoresponsible nasal gel |
| Cite Article: | "Design and Development Of Thermo-responsible Nanoparticles Containing Nasal Gel Of Lercanidipine", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 11, page no.a208-a225, November-2025, Available :http://www.ijrti.org/papers/IJRTI2511030.pdf |
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| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
| Publication Details: |
Published Paper ID: IJRTI2511030
Registration ID:207342
Published In: Volume 10 Issue 11, November-2025
DOI (Digital Object Identifier):
Page No: a208-a225 Country: Chhatarpur, Madhya Pradesh, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2511030 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2511030 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
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