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Medicinal plants have played a crucial role in traditional healthcare and remain a valuable source for modern drug discovery. Cassia auriculata L. (syn. Senna auriculata), commonly known as Tanner’s Cassia or Avaram Senna, is an evergreen shrub widely distributed in India, Sri Lanka, and folk medicine for treating diabetes, liver ailments, skin diseases, urinary infections, and digestive disorders. Almost all parts of the plant flowers, leaves, bark, seeds, and roots possess medicinal importance.
Phytochemical investigations reveal the presence of flavonoids (quercetin, kaempferol, rutin), tannins, glycosides, alkaloids, saponins, anthraquinones, steroids, and unique compounds such as auriculataosides. These secondary metabolites account for its wide spectrum of pharmacological activities. Experimental evidence has confirmed antidiabetic, antioxidant, anti-inflammatory, hepatoprotective, nephroprotective, antimicrobial, anticancer, cardioprotective, wound-healing, and immunomodulatory properties. Mechanistic studies highlight actions such as α-glucosidase inhibition, free radical scavenging, modulation of cytokines, and enhancement of antioxidant defense.
Toxicological studies indicates that the plant is generally safe at therapeutic doses, with no significant acute or sub-chronic toxicity observed in animal models. However, some reports of antifertility effects from seed extracts at high doses necessitate caution in reproductive-age populations. Despite strong preclinical evidence, human clinical trials remain limited, and further studies are required to establish standardized formulations, safe dosages, and clinical efficacy.
In conclusion, C. auriculata is a culturally significant medicinal plant with validated pharmacological potential. With further scientific exploration and sustainable utilization, it holds great promise for phytopharmaceutical development, particularly in the management of diabetes and oxidative stress related disorders.
Keywords:
Cassia auriculata, phytochemicals, pharmacological activities, traditional medicine, toxicity.
Cite Article:
"Comprehensive Review On Cassia Auriculata ; Traditional Uses,Pytochemistry,Pharmacology and Safety ", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 11, page no.b194-b203, November-2025, Available :http://www.ijrti.org/papers/IJRTI2511126.pdf
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator