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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | A BRIEF REVIEW ON : SOLUBILITY ENHANCEMENT TECHNIQUES OF POORLY SOLUBLE DRUGS. |
| Authors Name: | Durga M. Choudhari , Rutuja S. Divekar , Ajinath R. Sabale , Dr. Amita B. Dongare , Prof. Sandhya R. Kolekar |
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IJRTI_207695
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| Published Paper Id: | IJRTI2511175 |
| Published In: | Volume 10 Issue 11, November-2025 |
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| Abstract: | Poor water solubility remains a challenge in pharmaceutical development, particularly for biopharmaceutical classification system (bcs) class ii and iv drugs, which frequently display low dissolution rates and limited bioavailability. This review explores a spectrum of strategies both conventional and advanced for enhancing the solubility of such poorly soluble drugs. Techniques are categorized into chemical modifications (including salt formation, co-crystallization, co-solvency, hydrotropy, and the use of novel solubilizers), physical modifications (such as particle size reduction via micronization and nanosuspensions, crystal habit alteration through polymorphs and pseudopolymorphs, complexation including inclusion complexes, and drug dispersion in carriers via solid solutions and dispersions), and other innovative methods (notably ph adjustment, supercritical fluid processing, the liquisolid technique, and polymer based approaches). Each method is evaluated based on its impact on key performance parameters such as dissolution rate, saturation solubility, and bioavailability and its practicality for formulation development. The scope of this review emphasizes how crucial it is to choose suitable modification methods based on the physicochemical characteristics of potential drugs and the routes of administration they are intended to use. Finally, there is great potential for enhancing the therapeutic results of hydrophobic medications through the successful use of these solubility-enhancement techniques. |
| Keywords: | solubility, modification ,conventional method, particle size, solvency. |
| Cite Article: | "A BRIEF REVIEW ON : SOLUBILITY ENHANCEMENT TECHNIQUES OF POORLY SOLUBLE DRUGS.", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 11, page no.b689-b701, November-2025, Available :http://www.ijrti.org/papers/IJRTI2511175.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2511175
Registration ID:207695
Published In: Volume 10 Issue 11, November-2025
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Page No: b689-b701 Country: -, -, India Research Area: Engineering Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2511175 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2511175 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
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