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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 11
Issue Published : 117
Article Submitted : 21318
Article Published : 8476
Total Authors : 22301
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| Paper Title: | PROTECTIVE EFFECTS OF SALIDROSIDE AND TRICHOSTATIN A AGAINST SIMVASTATIN-INDUCED SKELETAL MYOPATHY: HISTOPATHOLOGICAL EVALUATION AND C2C12 CELL-LINE INVESTIGATION |
| Authors Name: | Kalubha Shivubha Zala , Dr. Jigneshkumar Dineshkumar Modi , Dr. Ravikumar R. Patel , Sheekha Umeshchandra Mishra , Dr. Parina Vitthalbhai Dobariya |
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IJRTI_208674
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| Published Paper Id: | IJRTI2512102 |
| Published In: | Volume 10 Issue 12, December-2025 |
| DOI: | |
| Abstract: | Background: Statins are widely prescribed lipid-lowering agents, but their use can be limited by skeletal muscle toxicity ranging from myalgia to severe myopathy. Oxidative stress, mitochondrial dysfunction, apoptosis, and impaired autophagy are implicated in statin-associated muscle injury. Salidroside (a Rhodiola rosea phenolic glycoside) shows antioxidant and mitochondrial protective activity, while Trichostatin A (TSA), a histone deacetylase inhibitor, may modulate autophagy and apoptosis—suggesting potential synergy as an adjunct strategy. Objective: To evaluate the protective potential of Salidroside and TSA (alone and in combination) against simvastatin-induced myopathy using (i) in vivo functional and biochemical assessment with histology, and (ii) in vitro C2C12 cell-line assays. Methods: Male Wistar rats (200–250 g) were randomized into treatment groups including simvastatin (80 mg/kg p.o.) and adjunct Salidroside (50 mg/kg i.p.) and/or TSA (0.6 mg/kg i.p.) for 15 days. Functional tests (rota-rod, open-field, righting reflex), serum CK/LDH, and H&E-based muscle histology grading were planned. In vitro, C2C12 myoblast viability was assessed by trypan blue counting, morphology, and MTT assay. Expected outcomes: Simvastatin is expected to elevate CK/LDH and worsen motor performance with degenerative histological changes; adjunct Salidroside and TSA are expected to reduce biochemical injury markers and improve histological and cell-viability outcomes. Conclusion: This integrated histology + cell-line design provides a translational framework to test Salidroside and TSA as potential adjunct candidates to mitigate statin-associated myopathy. Keywords: Statin-induced myopathy; Simvastatin; Salidroside; Trichostatin A; HDAC inhibitor; C2C12; Histopathology; Creatine kinase; Lactate dehydrogenase |
| Keywords: | Statin-induced myopathy; Simvastatin; Salidroside; Trichostatin A; HDAC inhibitor; C2C12; Histopathology; Creatine kinase; Lactate dehydrogenase |
| Cite Article: | "PROTECTIVE EFFECTS OF SALIDROSIDE AND TRICHOSTATIN A AGAINST SIMVASTATIN-INDUCED SKELETAL MYOPATHY: HISTOPATHOLOGICAL EVALUATION AND C2C12 CELL-LINE INVESTIGATION", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 12, page no.b22-b30, December-2025, Available :http://www.ijrti.org/papers/IJRTI2512102.pdf |
| Downloads: | 000131 |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2512102
Registration ID:208674
Published In: Volume 10 Issue 12, December-2025
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Page No: b22-b30 Country: Gandhinagar, Kalo, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2512102 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2512102 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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