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Paper Title
Formulation and Characterization of Lercanidipine Loaded Nanoparticles
Authors
Umesh Kumar Chaurasiya , Satyam Vishwakarma
Keywords
hypertension, bioavailability, nanoparticle, ercanidipine, extended release profile
Abstract
Aim of the present study was to investigate the potential of polymeric nanoparticles in improving the biopharmaceutical properties of lercanidipine. Lercanidipine loaded nanoparticles were prepared by modified emulsion-diffusion-solvent evaporation technique. The resulting nanoparticles were freeze dried and then characterized for particle size, zeta potential, encapsulation efficiency, DSC, XRD, AFM, TEM and in vitro drug release. Amongst all the screened batches, optimized batch (B. No. PN-05) exhibited a particle size of 200.2 nm, PDI of 0.130, zeta potential, -20.6 mV and encapsulation efficiency of 77.41%. The AFM analysis illustrated spherical, non-aggregated, smooth particles whereas TEM images showed smooth, regularly spherical homogeneous mass of the particles. DSC studies suggested amorphization of the drug in nanoparticles and same was also observed in XRD diffractograms as reflected by the amorphous humps. The optimized batch exhibited a significantly different drug release profile from that of lercanidipine. It showed an initial rapid release of 17.96% in 1 h and followed an extended release profile releasing 82.74% in 24 h. The novel polymeric lercanidipine nanoparticles demonstrated 2.12-fold increase in absolute bioavailability as compared to free lercanidipine. In conclusion, encapsulation of lercanidipine in nanoparticles forms a sound basis for improving its bioavailability and for better management of hypertension.
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IJRTI — journal style
"Formulation and Characterization of Lercanidipine Loaded Nanoparticles", IJRTI - International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2456-3315, Vol.10, Issue 12, page no.b284-b299, December-2025, Available :https://ijrti.org/papers/IJRTI2512138.pdf
APA — 7th edition
Chaurasiya, U. K., & Vishwakarma, S. (2025). Formulation and Characterization of Lercanidipine Loaded Nanoparticles. International Journal for Research Trends and Innovation, 10(12), b284-b299. https://ijrti.org/viewpaperforall.php?paper=IJRTI2512138
MLA — 9th edition
Chaurasiya, Umesh Kumar, and Satyam Vishwakarma. "Formulation and Characterization of Lercanidipine Loaded Nanoparticles." International Journal for Research Trends and Innovation, vol. 10, no. 12, 2025, pp. b284-b299, https://ijrti.org/viewpaperforall.php?paper=IJRTI2512138.
Chicago — 17th, bibliography
Chaurasiya, Umesh Kumar, and Satyam Vishwakarma. "Formulation and Characterization of Lercanidipine Loaded Nanoparticles." International Journal for Research Trends and Innovation 10, no. 12 (2025): b284-b299. https://ijrti.org/viewpaperforall.php?paper=IJRTI2512138.
Harvard — author–date
Chaurasiya, U.K. and Vishwakarma, S. (2025) 'Formulation and Characterization of Lercanidipine Loaded Nanoparticles', International Journal for Research Trends and Innovation, 10(12), pp. b284-b299. Available at: https://ijrti.org/viewpaperforall.php?paper=IJRTI2512138
IEEE — numbered reference
U. K. Chaurasiya and S. Vishwakarma, "Formulation and Characterization of Lercanidipine Loaded Nanoparticles," IJRTI, vol. 10, no. 12, pp. b284-b299, Dec. 2025.
Vancouver — biomedical
Chaurasiya UK, Vishwakarma S. Formulation and Characterization of Lercanidipine Loaded Nanoparticles. IJRTI. 2025 Dec;10(12):b284-b299.
AMA — 11th edition
Chaurasiya UK, Vishwakarma S. Formulation and Characterization of Lercanidipine Loaded Nanoparticles. IJRTI. 2025;10(12):b284-b299. Accessed at https://ijrti.org/viewpaperforall.php?paper=IJRTI2512138
BibTeX — Zotero, Mendeley, LaTeX
@article{IJRTI2512138,
author = {Umesh Kumar Chaurasiya and Satyam Vishwakarma},
title = {Formulation and Characterization of Lercanidipine Loaded Nanoparticles},
journal = {International Journal for Research Trends and Innovation},
volume = {10},
number = {12},
pages = {b284-b299},
year = {2025},
month = {December},
issn = {2456-3315},
url = {https://ijrti.org/viewpaperforall.php?paper=IJRTI2512138}
}
RIS — EndNote, RefWorks
TY - JOUR
AU - Chaurasiya, Umesh Kumar
AU - Vishwakarma, Satyam
TI - Formulation and Characterization of Lercanidipine Loaded Nanoparticles
T2 - International Journal for Research Trends and Innovation
JA - IJRTI
VL - 10
IS - 12
PY - 2025
SN - 2456-3315
UR - https://ijrti.org/viewpaperforall.php?paper=IJRTI2512138
SP - b284-b299
ER -
Issue
Volume 10 Issue 12,
December-2025
Pages : b284-b299
Other Publication Details
Paper Reg. ID
IJRTI_208419
Published Paper ID
IJRTI2512138
Downloads
205,608
Research Area
Pharmacy
Country
Chhatarpur, Madhya Pradesh, India
Published
December 2025
Published Paper PDF
https://ijrti.org/papers/IJRTI2512138.pdf
Published Paper URL
https://ijrti.org/viewpaperforall.php?paper=IJRTI2512138
About Publisher
International Journal for Research Trends and Innovation
Published by IJRTI (JW Publication)
2456-3315
ISSN
10.57
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2016
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Declarations
Funding
No external funding was received for this study.
Conflict of Interest
The authors declare that they have no conflict of interest.
Acknowledgements
The authors would like to thank the reviewers and the editorial board of International Journal for Research Trends and Innovation for their careful reading and constructive comments, and all colleagues who supported the preparation of this manuscript.
