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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Issue: February 2026
Volume 11 | Issue 2
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Impact Factor : 8.14
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| Paper Title: | Conceptual Analysis of Kha Vaigunya within the Shatkriyakala Framework in Adult-Onset Neurodegenerative Diseases: A Narrative Review |
| Authors Name: | Dr. Pushpendra Kumar Pandey |
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IJRTI_209213
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| Published Paper Id: | IJRTI2601062 |
| Published In: | Volume 11 Issue 1, January-2026 |
| DOI: | |
| Abstract: | Adult-onset neurodegenerative diseases (AONDs) comprise a heterogeneous group of disorders marked by progressive, age-dependent neuronal dysfunction, with synaptic and axonal impairments preceding overt neuronal loss. Despite diverse genetic and environmental triggers, these diseases share common pathological trajectories that remain inadequately explained by late-stage molecular or cellular events alone. Ayurveda provides an alternative, stage-based understanding of disease evolution through the framework of Shatkriyakala, within which Kha Vaigunya—defined as a latent defect or vulnerability in channels of transport and transformation (srotas)—is recognized as a prerequisite for disease manifestation. This narrative review critically examines classical Ayurvedic descriptions of Kha Vaigunya and Shatkriyakala alongside contemporary neuroscientific evidence on AONDs. The analysis demonstrates that early, silent disturbances described in the initial stages of Shatkriyakala correspond closely with preclinical synaptic and axonal dysfunction documented in AONDs. Kha Vaigunya is identified as a disease-producing cause (utpadaka hetu), facilitating localization of pathology (sthana samshraya) and explaining selective neuronal vulnerability, prolonged latency, and progressive disease course observed in AONDs. The synthesis highlights a conceptual convergence between Ayurvedic and modern biomedical models, wherein impaired transport and communication systems represent a common substrate underlying neurodegenerative progression. This integrative perspective provides a structured understanding of early disease evolution in AONDs and establishes a foundation for further discussion on preventive and therapeutic considerations. |
| Keywords: | Kha Vaigunya; Shatkriyakala; Adult-onset neurodegenerative diseases; Axonal transport; Srotas |
| Cite Article: | "Conceptual Analysis of Kha Vaigunya within the Shatkriyakala Framework in Adult-Onset Neurodegenerative Diseases: A Narrative Review", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.11, Issue 1, page no.a448-a451, January-2026, Available :http://www.ijrti.org/papers/IJRTI2601062.pdf |
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| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2601062
Registration ID:209213
Published In: Volume 11 Issue 1, January-2026
DOI (Digital Object Identifier):
Page No: a448-a451 Country: Indore, Madhya Pradesh, India Research Area: Health Science Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2601062 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2601062 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
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