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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Issue: March 2026
Volume 11 | Issue 3
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Impact Factor : 8.14
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Volume Published : 11
Issue Published : 118
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| Paper Title: | INVESTIGATING THE EFFICACY OF CURCUMIN NANOPARTICLE CAPSULES FOR ENHANCING BIOAVAILABILITY AND ANTI-INFLAMMATORY ACTIVITY |
| Authors Name: | Ms.Jyoti Thakur , Dr.Dhyanendra Singh Baghel |
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IJRTI_209512
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| Published Paper Id: | IJRTI2601127 |
| Published In: | Volume 11 Issue 1, January-2026 |
| DOI: | |
| Abstract: | Curcumin, a naturally occurring polyphenolic compound isolated from Curcuma longa, exhibits significant anti-inflammatory, antioxidant, and therapeutic potential. Despite its promising pharmacological profile, the clinical application of curcumin is severely limited due to poor aqueous solubility, low gastrointestinal absorption, rapid metabolism, and swift systemic elimination, resulting in low bioavailability. Nanoparticle-based capsule formulations have emerged as an advanced drug delivery strategy to overcome these limitations. This review critically examines recent advances in curcumin nanoparticle capsule systems and their role in enhancing bioavailability and anti-inflammatory efficacy. Various nanocarriers, including polymeric nanoparticles, lipid-based systems, and polysaccharide-derived nanocapsules, are discussed with respect to formulation design, pharmacokinetic improvements, and mechanisms of action. Evidence from preclinical and emerging clinical studies demonstrates that nanoparticle encapsulation significantly improves curcumin stability, intestinal absorption, plasma concentration, and targeted delivery to inflamed tissues. Furthermore, nanocurcumin formulations exhibit superior suppression of pro-inflammatory mediators such as nuclear factor-κB (NF-κB), tumor necrosis factor-α (TNF-α), and interleukins when compared with conventional curcumin. Overall, curcumin nanoparticle capsules represent a promising approach for maximizing therapeutic efficacy and expanding the clinical applicability of curcumin in the management of inflammatory disorders. |
| Keywords: | Curcumin, Nanoparticle capsules, Bioavailability, Anti-inflammatory activity, Nanomedicine. |
| Cite Article: | "INVESTIGATING THE EFFICACY OF CURCUMIN NANOPARTICLE CAPSULES FOR ENHANCING BIOAVAILABILITY AND ANTI-INFLAMMATORY ACTIVITY", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.11, Issue 1, page no.b204-b210, January-2026, Available :http://www.ijrti.org/papers/IJRTI2601127.pdf |
| Downloads: | 00089 |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2601127
Registration ID:209512
Published In: Volume 11 Issue 1, January-2026
DOI (Digital Object Identifier):
Page No: b204-b210 Country: Indore, IN, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2601127 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2601127 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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