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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Issue: April 2026
Volume 11 | Issue 4
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 11
Issue Published : 119
Article Submitted : 22653
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| Paper Title: | Comparative Analysis of Macrophage Phagocytic Efficiency Against Multidrug-Resistant Clinical Bacterial Isolates |
| Authors Name: | Reshma Shikalgar , Girish Pathade |
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IJRTI_210091
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| Published Paper Id: | IJRTI2602135 |
| Published In: | Volume 11 Issue 2, February-2026 |
| DOI: | |
| Abstract: | In this study around the world, superbugs resistant to many drugs now pose a serious public health issue because few treatments remain effective. Bacteria like Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, along with Pseudomonas aeruginosa, often cause infections picked up in hospitals - these tend to worsen outcomes and lead to more deaths. At the frontlines of defence, macrophages clear pathogens through a process known as phagocytosis, helping protect the body from day one. Still, some MDR bacteria might outsmart the body's clean-up cells. This research looks at how well immune fighters grab and destroy different types of drug-resistant versus regular bacteria found in patients. Bacteria samples come from real cases, checked by usual lab methods to confirm their presence. After finding which ones are present, tests with antibiotics show which resist multiple drugs. A lab-based setup involving macrophage cells grown from lines will be created through differentiation. Measuring how these cells take in particles involves tracking the phagocytic index along with bacterial survival inside them. Instead of just guessing, actual counts using CFU analysis after gentamicin treatment give clear numbers. On top of that, measuring ROS levels shows whether oxidative bursts happen as expected. Looking at the results, differences in how macrophages clear MDR compared to non-MDR bacteria might come into view, offering clues about behaviour between host and germ. One outcome could be new angles on how immunity works when pathogens adapt. Such work may later feed into exploring macrophages as a back-up way to fight drug-resistant infections. |
| Keywords: | Resistant (MDR) Bacteria, Macrophage Phagocytosis, Innate Immunity, Intracellular Killing, Reactive Oxygen Species (ROS), Host–Pathogen Interaction. |
| Cite Article: | "Comparative Analysis of Macrophage Phagocytic Efficiency Against Multidrug-Resistant Clinical Bacterial Isolates", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2456-3315, Vol.11, Issue 2, page no.b263-b272, February-2026, Available :http://www.ijrti.org/papers/IJRTI2602135.pdf |
| Downloads: | 00079 |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2602135
Registration ID:210091
Published In: Volume 11 Issue 2, February-2026
DOI (Digital Object Identifier):
Page No: b263-b272 Country: Kolhapur , Maharashtra, India Research Area: Life Sciences Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2602135 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2602135 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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