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A validated RP HPLC method for the estimation of canagliflozin in tablet dosage form on Inertsil ODS C18 (250 x 4.6 x 5 µ column) using mobile phase consisting of methanol and acetonitrile with ratio of 60:40 v/v. Flow rate was maintained at 1.2 mL/min with 254 nm UV detection. The retention time obtained for canagliflozin was at 2.8 min. The detector response was linear in the concentration range of 10 – 250 µg/mL. This method has been validated and shown to be specific, sensitive, precise, linear, accurate, rugged, robust and fast. Hence, this method can be applied for routine quality control of canagliflozin tablet dosage forms as well as in bulk drug.
Keywords:
RP-HPLC, Canagliflozin, UV.
Cite Article:
"Development and Validation of Novel RP-HPLC method for the estimation of Canagliflozin in bulk and pharmaceutical dosage forms", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.6, Issue 2, page no.28 - 31, February-2021, Available :http://www.ijrti.org/papers/IJRTI2102007.pdf
Downloads:
000204861
ISSN:
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator