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Abstract:
Purpose: Since the release of HPV vaccines in 2006, 100 countries have included the HPV vaccines in their vaccination programs. In India, the data on prevalence of HPV types other than HPV 16 and 18 are lacking especially from the western region. Therefore, the present investigation aimed to evaluate the prevalence of the HPV strains included in the current nonavalent vaccine.
Method: DNA was isolated from 400 samples and endpoint TS-PCR was conducted to detect HPV 16, 18, 31, 33, 45, 52, 58, 6 and 11. The data were analyzed by chi square test using SPSS software version 20.
Result: The total HPV prevalence in this studied cohort was 77.8%. All the HPV types except HPV 11 were present in the studied cohort. HPV 16 (74.2%), HPV 18 (14.8%) and HPV 45 (4%) were observed to be comparatively higher than the other HPV type. Moreover, HPV 16 was noted to be significantly higher in cases with lymph node metastasis (p=0.015)
Conclusion: The HPV infections are prominently prevalent in the cervical cancer cohort from the western region of India. The data in the present study will be useful in strengthening the HPV vaccination programs in India.
Keywords:
HPV strains, cervical cancer, screening, TS-PCR
Cite Article:
"Nonavalent strains of Human papilloma virus in the cervical cancer patients from western India", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 6, page no.567 - 573, June-2022, Available :http://www.ijrti.org/papers/IJRTI2206094.pdf
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ISSN:
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator