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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | Evaluation of the acute and subchronic toxicity of the 95% hydroethanolic extract of Bauhinia rufescens leaves in albino Wistar rats. |
| Authors Name: | Josias Djenguemtar , Siméon Pierre Chegaing Fodouop , Benjamin T. Talom , Elodie Yamako Konack , Donatien Gatsing |
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IJRTI_188209
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| Published Paper Id: | IJRTI2310060 |
| Published In: | Volume 8 Issue 10, October-2023 |
| DOI: | |
| Abstract: | B. rufescens is a plant widely used in traditional medicine in Chad for the treatment of typhoid fever. However, its toxicity has been little studied. The acute and subchronic toxicity of the 95% hydroethanolic extract of B. rufescens leaves was studied in albino Wistar rats. The acute toxicity study was carried out on nine nulliparous, non-pregnant rats aged 10 weeks and weighing between 145 and 177g. The subchronic toxicity study was carried out on 48 albino Wistar rats divided into six equal groups of 4 males and 4 females, the animals being caged individually. During 14 days of observation after gavage, the 2000 and 5000 mg/kg dose limits did not cause any abnormal behavior or death in the animals; no clinical signs were observed. The LD50 would therefore be higher than the 5000 mg/kg dose. The relative weights of organs (liver, lungs, kidneys, heart, spleen and ovary) removed from rats at the end of subchronic treatment did not vary significantly. However, test animals showed a significant (p<0.05) increase in weight growth on days 8 and 14 compared with control animals. Biochemical analyses showed a significant (P<0.05) decrease in plasma transaminase (ALAT) and plasma alkaline phosphatase (PAL) activity in animals of both sexes at all doses compared with control animals. Similarly, a significant decrease (p<0.05) in plasma creatinine levels in male animals at all dose levels was followed by a significant increase in urinary creatinine levels in both sexes compared to control animals. A significant decrease (p<0.05) in LDL-cholesterol and atherogenic index followed by a significant increase (p<0.05) in HDL-cholesterol at all doses compared with control animals. Hematological analyses of the extract produced no significant changes (p<0.05) in white blood cell count and red blood cell count parameters at all doses in either sex compared with control animals. Histological examination of the 95% hydroethanolic extract of B. rufescens leaves at various doses produced no adverse effects on the liver, kidney, testicular or ovarian tissues of the test animals. The study demonstrated the safety or non toxic potential of the 95% hydroethanolic extract of B. rufescens leaves on liver function, and would be favorable to the production of an improved traditional medicine. |
| Keywords: | Bauhinia rufescens; Acute toxicity; Subchronic toxicity. |
| Cite Article: | "Evaluation of the acute and subchronic toxicity of the 95% hydroethanolic extract of Bauhinia rufescens leaves in albino Wistar rats.", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 10, page no.417 - 437, October-2023, Available :http://www.ijrti.org/papers/IJRTI2310060.pdf |
| Downloads: | 000205156 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2310060
Registration ID:188209
Published In: Volume 8 Issue 10, October-2023
DOI (Digital Object Identifier):
Page No: 417 - 437 Country: Dschang, WEST, Cameroon Research Area: Biological Science Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2310060 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2310060 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
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