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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | A Review article on Mucoadhesive drug delivery system: An important formulation generated in Novel Drug Delivery Systems |
| Authors Name: | Anjali Prabhakar Bangar , Prof.Ankita P. Jatale , Dr.Swati P.Deshmukh |
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IJRTI_188194
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| Published Paper Id: | IJRTI2310061 |
| Published In: | Volume 8 Issue 10, October-2023 |
| DOI: | |
| Abstract: | Abstract The mucus layer that covers the mucosal epithelial surface and mucin molecules interact with mucoadhesive drug delivery methods to prolong the duration the dosage form spends at the absorption site. This review addresses the mechanisms and theories underlying mucoadhesion, the influences on mucoadhesive devices, as well as numerous mucoadhesive dose forms. By creating innovative drug delivery methods, drug effects can be improved. Several in vitro and in vivo methodologies are suggested for understanding its mechanisms. Through a variety of contact methods, the mucoadhesive formulation can stick to the mucosal membrane and improve the retention and permeability of bioactive substances. Bioactive substances can be absorbed from the mucosa, which avoids the hepatic first-pass metabolism and gastrointestinal transit, to increase bioavailability.The food industry accepts a variety of mucoadhesive polymers, emulsifiers, and thickeners used in pharmaceutical formulation. In the nutraceutical industry, the introduction of mucoadhesive formulations will be a game-changer because we are still exploring new strategies to increase the bioavailability of several bioactive substances. Mucoadhesive drug delivery systems may be affected by the mucus barrier, which covers mucin molecules and the mucosal epithelial surface. This interaction lengthens the dose form's stay at the site of absorption, boosting therapeutic outcomes and drug bioavailability and effectiveness. In order to improve the pattern of drug release, solubility, and dissolution of medications that are insufficiently soluble, polymers are utilized to give muco-adhesion to the dosage form. Using interfacial forces, two components, one of which is biological, can be held together for long periods of time in a condition known as Mucoadhesion. The mucosa has a lot of blood flow and is fairly permeable. Readers will gain a better grasp of this medication delivery technique, its formulation options, and its benefits and drawbacks after reading this review. Bypassing the first-pass effect, a novel drug delivery technique known as buccal drug delivery allows the medication to reach the systemic circulation quickly. |
| Keywords: | Key word: MDDS , Mucoadhesion, Bioadhesion, Control Drug Release |
| Cite Article: | "A Review article on Mucoadhesive drug delivery system: An important formulation generated in Novel Drug Delivery Systems", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 10, page no.438 - 443, October-2023, Available :http://www.ijrti.org/papers/IJRTI2310061.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2310061
Registration ID:188194
Published In: Volume 8 Issue 10, October-2023
DOI (Digital Object Identifier):
Page No: 438 - 443 Country: Washim, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2310061 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2310061 |
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ISSN: 2456-3315
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