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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | SPECTROPHOTOMETRIC OXIDATION METHOD FOR THE DETERMINATION OF RISPERIDONE IN THE PRESENCE OF TRIHEXYPHENYDYL HCl BY USING BROMATE – BROMIDE MIXTURE AS AN OXIDANT |
| Authors Name: | I. Lakshmi Prasanna , G.T. Naidu , Nuzhath Fathima , I.E.Chakravarthy , G. Abdul Huq |
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IJRTI_180396
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| Published Paper Id: | IJRTI1808006 |
| Published In: | Volume 3 Issue 8, August-2018 |
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| Abstract: | A simple, sensitive, precise and accurate spectrophotometric method has been developed for the estimation of Risperidone in the presence of Trihexyphenydyl in pharmaceutical formulations and in the drug dosage form. During the study, it is observed that acidic solution of the drug formed the oxidation product with Bromate – Bromide mixture. This property of the drug is exploited for the development of spectrophotometric method for the determination and analysis of the drug. The oxidation product showed λmax at 320 nm. The linearity range for Risperidone in the presence of Trihexyphenydyl is found to be 10 μg/ml to 250 μg/ml. Recovery studies gave satisfactory results indicating that none of the common additives and excipients interfere in the assay method. The molar absorptivity and the sandell sensitivity of the method are evaluated and the values are found to be to be 0.9153×104 lit/ mole/cm and 0.0448 μg/ ml/ cm2 respectively. |
| Keywords: | Spectrophotometry, Risperidone, Trihexyphenydyl HCl, Bromate-Bromide oxidant, Pharmaceutical formulations |
| Cite Article: | "SPECTROPHOTOMETRIC OXIDATION METHOD FOR THE DETERMINATION OF RISPERIDONE IN THE PRESENCE OF TRIHEXYPHENYDYL HCl BY USING BROMATE – BROMIDE MIXTURE AS AN OXIDANT", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2456-3315, Vol.3, Issue 8, page no.28 - 32, August-2018, Available :http://www.ijrti.org/papers/IJRTI1808006.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI1808006
Registration ID:180396
Published In: Volume 3 Issue 8, August-2018
DOI (Digital Object Identifier):
Page No: 28 - 32 Country: UPPAL,HYDERABAD, TELANGANA, India Research Area: Physics Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI1808006 Published Paper PDF: https://www.ijrti.org/papers/IJRTI1808006 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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