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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | Detection of Pvl gene for the presence of leukocidin among clinical isolates of staphylococcus aureus |
| Authors Name: | Pavithra K , Mr.Gopinath , Dr. M.S.Niveditha |
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IJRTI_181135
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| Published Paper Id: | IJRTI2002012 |
| Published In: | Volume 5 Issue 2, February-2020 |
| DOI: | |
| Abstract: | Aim:- Detection of Pvl gene for the presence of leukocidin among clinical isolates of staphylococcus aureus Background:-PVL and γ -haemolysin are considered to be members of a toxin family known as synergohymenotropic toxins, as they act on cell membranes by the synergy of two proteins that form a pore. Only 2% of S. aureus isolates produce PVL, while γ -haemolysin is produced by more than 99% of S. aureus isolates. PVL is the most leukocytolytic toxin in the family, however it does not exhibits no haemolytic activity on human erythrocytes. A sum of 20 clinical isolates of S. aureus were subjected to antibiotic sensitivity pattern followed by the detection of pvl gene by PCR. We have observed increased resistance to most of the routinely used antibiotics and 10% of our isolates found to have pvl gene. As this gene is directly associated with skin and soft tissue infections by S. aureus, our two isolates may even cause such infections, although none of these strains were not obtained from cutaneous lesions. Panton–Valentine leukocidin (PVL) is one of many toxins associated with S. aureus infection. Because it can be found in virtually all CA-MRSA strains that cause soft-tissue infections, it was long described as a key virulence factor, allowing the bacteria to target and kill specific white blood cells known as neutrophils. This view was challenged, however, when it was shown that removal of PVL from the two major epidemic CA-MRSA strains resulted in no loss of infectivity or destruction of neutrophils in a mouse model. Materials and Method:- These antibiotics were procured from Himedia, Mumbai. This was performed by Kirby-bauer disc diffusion method as per CLSI guidelines. Conclusion:- The pathogenicity of Staphylococcus aureus depends on various bacterial surface components and extracellular proteins. uggests that the Panton-Valentine leukocidin (PVL) is 1 such virulence factor that has a major role in pathogenicity. |
| Keywords: | Staphylococcus aureus, Pvl gene, PCR, Leukocidin ,Haemolysin. |
| Cite Article: | "Detection of Pvl gene for the presence of leukocidin among clinical isolates of staphylococcus aureus", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.5, Issue 2, page no.60 - 65, February-2020, Available :http://www.ijrti.org/papers/IJRTI2002012.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2002012
Registration ID:181135
Published In: Volume 5 Issue 2, February-2020
DOI (Digital Object Identifier):
Page No: 60 - 65 Country: Chennai, Tamil Nadu, India Research Area: Biological Science Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2002012 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2002012 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
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