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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | DESIGN AND OPTIMIZATION OF MICROCRYSTAL PRODUCED BY SONOPRECIPITATION TECHNIQUE: OPTIMIZATION OF PROCESS PARAMETERS |
| Authors Name: | Dheeraj Kadam , - , - , - , - |
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IJRTI_187364
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| Published Paper Id: | IJRTI2110017 |
| Published In: | Volume 6 Issue 10, October-2021 |
| DOI: | |
| Abstract: | The aim of the present work was to prepare microparticles by sonoprecipitation method for targeted drug delivery of Beclometasone dipropionate (BDP), an anti-inflammatory corticosteroid available for the treatment of asthma. Experimental designing employed using Design-Expert 5.0 software (StatEase, QD Consulting, Penzance, UK) with linear as design model. The factors investigated were addition rate, stabilizer conc. and sonication time. The addition rate of solvent i.e acetone was studied at 50(-1), 100(0) and 150(1) g /min, stabilizer conc. were 0.5(1), 1(0) and 1.5 %( 1) and sonication time investigated were 1(-1), 2(0) and 3 (1) min. Dry powder were characterized by XRD, DSC, SEM, FTIR, flow property, Particle Size, Particle Distribution and Aerodynamic Particle Size Analysis.It is worth that the particles were uniform in the presence of long time of sonication showed the highest FPF loaded and FPF emitted of 41 (2%) and 84( 4%) respectively, depositing mainly on stages 3 and 4, with much lower amounts collected on the higher stages of the MSLI. Highlights: • Developed spherical microparticles with size range of 1to 5 µm. • Factors investigated were addition rate, stabilizer conc. and sonication time. • Highest Fine Particle Fraction loaded of 41 (2%) and emitted 84(4%) respectively. |
| Keywords: | Beclometasone dipropionate, Sonoprecipitation technique, Central Composite Design, Crystal engineering. |
| Cite Article: | "DESIGN AND OPTIMIZATION OF MICROCRYSTAL PRODUCED BY SONOPRECIPITATION TECHNIQUE: OPTIMIZATION OF PROCESS PARAMETERS", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.6, Issue 10, page no.136 - 150, October-2021, Available :http://www.ijrti.org/papers/IJRTI2110017.pdf |
| Downloads: | 000204834 |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2110017
Registration ID:187364
Published In: Volume 6 Issue 10, October-2021
DOI (Digital Object Identifier):
Page No: 136 - 150 Country: Latur, Maharashtra, India Research Area: Physics Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2110017 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2110017 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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