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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 11
Issue Published : 118
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| Paper Title: | A Novel Microparticles for Antimicrobial Activity |
| Authors Name: | Manisha Sahu , Mrs. Anju mishra , Raju Sahu , Keshav Chandravanshi , Satish Sahu |
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| Author Reg. ID: |
IJRTI_182377
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| Published Paper Id: | IJRTI2206141 |
| Published In: | Volume 7 Issue 6, June-2022 |
| DOI: | |
| Abstract: | Abstract: The current study concern with the preparation and evaluation of microparticle using HPMC and Ethylcellulose as polymer in the view of effectiveness, and easy of availability, cost effectiveness with sulphamethoxazole as model drug. Sulphamethoxazole is an active anti-bacterial drug having biological half-life of 8-10 hours and 86%-98% bioavailability and licensed for the treatment bacterial infection Microparticle of sulphamethoxazole were prepared using HPMC & EC by solvent evaporation technique. Compatibility study was carried out by using FTIR at the range of 4000 to 400 cm-1 shows no significant change in the characteristic peaks of sulphamethoxazole and excipients in all the formulation, which indicates the compatibility of sulphamethoxazole with excipients. The prepared microspheres were analysed for particle size, Micromeritic properties, % yield, % drug entrapment efficiency, in-vitro drug release studies, and antimicrobial activity and stability studies. spherical shape and size range of 100µm to 200µm. In-vitro drug release shows decreases as concentration of HPMC increases. We conclude that, microparticle offer a practical and suitable approach to prepare controlled Microparticles thus obtained were found to white colour and free flowing. Micromeritic studies of the prepared formulations are found within the prescribed limits and indicated good flow property. The Scanning Electron Microscopy (SEM) studies inferred the release of sulphamethoxazole with HPMC and EC as rate controlling agent to enhance bioavailability and reduction in dose frequency as well as patient compatibility. |
| Keywords: | Keywords: Sulphamethoxazole, microparticle antibacterial, HPMC, EC and controlled release |
| Cite Article: | "A Novel Microparticles for Antimicrobial Activity", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 6, page no.849 - 861, June-2022, Available :http://www.ijrti.org/papers/IJRTI2206141.pdf |
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| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2206141
Registration ID:182377
Published In: Volume 7 Issue 6, June-2022
DOI (Digital Object Identifier):
Page No: 849 - 861 Country: Janjgir champa , Chhattisgarh, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2206141 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2206141 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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