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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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| Paper Title: | PHARMACOLOGICAL ACTION OF DEFLAZACORT: A REVIEW |
| Authors Name: | Neha Sharma , Punam Gaba , Shilpa kumari |
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| Author Reg. ID: |
IJRTI_187596
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| Published Paper Id: | IJRTI2307071 |
| Published In: | Volume 8 Issue 7, July-2023 |
| DOI: | |
| Abstract: | Deflazacort comes under the category of BCS class II and this drug is an immunosuppressant and anti-inflammatory drug which is a corticosteroid prodrug various parameters have been studied such as related to the introduction of the drug, various name of drug in different countries and the history of the drug and its origin parts related to chemistry such as structure, molecular weight, IUPAC and regarding to the pharmacology various parameters of pharmacokinetics. Studies on rats, however, showed that the medication had high levels in the liver and kidneys, medium levels in the cardiac, pancreas, pulmonary, and submaxillary glands, low levels in articular cartilage, striated muscle, the spleen, the gonads, and the thymus, and extremely low levels in the brain. The area under the time vs. plasma concentration curve, the half-life, and the total bioavailability via oral ingestion. Detailed pharmacodynamics properties like mechanism of action of deflazacort was studied which explain how the hormone bind to the receptor and show its anti-inflammatory and immunomodulatory effect impact on the mononuclear cells and impact on glucose metabolism were studied that include absorption, distribution, metabolism, excretion, half-life of the drug, mechanism of action, various therapeutic action have been checked out related to the rheumatoid arthritis, and related to the chronic juvenile arthritis, Asthma and Other Airways Diseases, Nephrotic Syndrome. Tolerability and oral dosage administration. The reference glucocorticoid prednisone has a suggested dosage range of. Deflazacort is less powerful than prednisone and is frequently given in larger proportions. In general, investigations to evaluate the dose equivalent of deflazacort and prednisone discovered that deflazacort was less powerful than prednisone, resulting in a dosage ratio. Despite these drawbacks, deflazacort showed comparable effectiveness to prednisone and methylprednisolone in treating rheumatoid arthritis, as well like prednisone in treating individuals with nephrotic syndrome. |
| Keywords: | Deflazacort, corticosteroid, chemistry, rheumatoid arthritis, and glucocorticoid. |
| Cite Article: | "PHARMACOLOGICAL ACTION OF DEFLAZACORT: A REVIEW", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 7, page no.481 - 490, July-2023, Available :http://www.ijrti.org/papers/IJRTI2307071.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2307071
Registration ID:187596
Published In: Volume 8 Issue 7, July-2023
DOI (Digital Object Identifier):
Page No: 481 - 490 Country: Ropar , Punjab, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2307071 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2307071 |
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ISSN: 2456-3315
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