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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Volume 11 | Issue 3
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Impact Factor : 8.14
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| Paper Title: | FORMULATION DESIGN AND EVALUATION OF POLYMERIC NANOPARTICLES OF LOVASTATIN BY 32 FACTORIAL DESIGN |
| Authors Name: | K.v.s.s Annapuran , A.Namitha sri , N.Eswari , P.Sri Sai Mounika reddy , P.Sudheer kumar, T.Pravallika |
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IJRTI_201063
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| Published Paper Id: | IJRTI2503024 |
| Published In: | Volume 10 Issue 3, March-2025 |
| DOI: | |
| Abstract: | Lovastatin is an Oral Antilipidemic Drug Which inhibit the HMG- COA reductase used in the treatment of Hypercholesterolemia and Coronary Heart Disease. This study aim to design and develop Lovastatin loaded Nanoparticles using 32 factorial design to optimize formulation parameters for sustained drug release by using Nanoprecipitation Method. The 32 factorial design was employed to evaluate the effects of Eudragit L-100(X1) and TPP(X2) are independent variables Concentration on critical parameters like particle size(Y1) and Percentage of drug release(Y2) are dependent variables that the optimization techniques provides on efficient and economical method to give the essential information and help to understand the relation between controlled independent and dependent variable. The FTIR, SEM and Zetapotential studies are conducted. The result shows optimized formulation exhibited sustained release profile with 99.42% of drug being released over a 12hrs, following Non-fickian release kinetics. The study demostrates the potential of Lovastatin loaded Eudragit L-100 and Tpp Nanoparticles as a promising approach for Sustained drug delivery, offering advantages in terms of improved bioavailability, reducing dosing frequency and enhanced patient compliance. |
| Keywords: | Lovastatin, Antilipidemic agent, TPP, Eudragit L-100, FTIP, SEM, Non-fickian release kinetics. |
| Cite Article: | "FORMULATION DESIGN AND EVALUATION OF POLYMERIC NANOPARTICLES OF LOVASTATIN BY 32 FACTORIAL DESIGN", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 3, page no.a196-a210, March-2025, Available :http://www.ijrti.org/papers/IJRTI2503024.pdf |
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| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2503024
Registration ID:201063
Published In: Volume 10 Issue 3, March-2025
DOI (Digital Object Identifier):
Page No: a196-a210 Country: -, -, India Research Area: Engineering Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2503024 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2503024 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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