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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | formulation and evaluation of controlled release floating tablets of pregabalin |
| Authors Name: | Supriya Udayagiri , C. Meenakshi , K. Manasa , R.Gnanamayee , sindhu gowda |
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IJRTI_202198
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| Published Paper Id: | IJRTI2504087 |
| Published In: | Volume 10 Issue 4, April-2025 |
| DOI: | |
| Abstract: | The present study focuses on the formulation and evaluation of controlled release floating tablets of Pregabalin to enhance its gastric retention time and provide sustained drug release, thereby improving therapeutic efficacy and patient compliance. Pregabalin, a widely used antiepileptic and neuropathic pain-relieving agent, has a short half-life and requires frequent dosing. To address these limitations, floating drug delivery systems (FDDS) were developed using hydrophilic polymers such as Hydroxypropyl Methylcellulose (HPMC K4M/K15M), Carbopol 934P, and Xanthan gum, in combination with gas-generating agents like sodium bicarbonate and citric acid. The tablets were prepared by direct compression and evaluated for pre-compression and post-compression parameters including hardness, friability, weight variation, drug content, floating lag time, total floating time, swelling index, and in vitro drug release. Dissolution studies were conducted in 0.1 N HCl (pH 1.2) to simulate gastric conditions, and the drug release data were analyzed using various kinetic models to determine the release mechanism. Among the formulations, the optimized batch demonstrated excellent floating behavior with a floating lag time of less than 1 minute and total floating time exceeding 12 hours. It also showed a controlled release of Pregabalin over 12 hours, fitting best to the Korsmeyer-Peppas model, indicating a diffusion-controlled mechanism. Stability studies conducted as per ICH guidelines confirmed the formulation’s physical and chemical stability over time. The results suggest that the developed floating tablets of Pregabalin offer a promising controlled release system capable of improving bioavailability and reducing dosing frequency. |
| Keywords: | Pregabalin, floating tablets, controlled release, FDDS, HPMC, drug release kinetics, gastroretentive system. |
| Cite Article: | "formulation and evaluation of controlled release floating tablets of pregabalin", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 4, page no.a676-a705, April-2025, Available :http://www.ijrti.org/papers/IJRTI2504087.pdf |
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| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2504087
Registration ID:202198
Published In: Volume 10 Issue 4, April-2025
DOI (Digital Object Identifier):
Page No: a676-a705 Country: Nellore, andhrapradesh, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2504087 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2504087 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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