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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Volume 10 | Issue 12
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Impact Factor : 8.14
Issue per Year : 12
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Issue Published : 115
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| Paper Title: | CRISPR-Cas9: Opportunities and Challenges in the Therapeutic Landscape of Leukemia |
| Authors Name: | Jalormi Vora , Urjita Sanghavi |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJRTI_207095
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| Published Paper Id: | IJRTI2510139 |
| Published In: | Volume 10 Issue 10, October-2025 |
| DOI: | |
| Abstract: | Leukemia, a heterogeneous group of hematologic malignancies originating from aberrant proliferation of hematopoietic stem and progenitor cells, remains one of the leading causes of cancer-related morbidity and mortality worldwide. Despite significant progress in chemotherapy, radiotherapy, hematopoietic stem cell transplantation (HSCT), and immunotherapeutic approaches, disease relapse and therapy resistance continue to present major obstacles to long-term remission. The emergence of the clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated protein 9 (Cas9) system has revolutionized genome editing, offering a simple, precise, and programmable tool for targeted gene manipulation. CRISPR-Cas9 has been applied extensively to dissect leukemogenic pathways, identify novel oncogenic drivers, and develop innovative therapeutic strategies, including gene correction, immunotherapy enhancement, and synthetic lethality screening. However, its translation into clinical oncology remains challenged by off-target mutagenesis, delivery inefficiencies, ethical considerations, and regulatory barriers. This review critically examines the mechanistic principles of CRISPR-Cas9, its therapeutic potential in leukemia, and the evolving landscape of CRISPR-based clinical research, while highlighting future prospects such as base editing, prime editing, and Cas variants that may improve safety and precision. |
| Keywords: | CRISPR-Cas9; Leukemia; Genome editing; Immunotherapy; Gene correction; Off-target effects; Cancer therapeutics |
| Cite Article: | "CRISPR-Cas9: Opportunities and Challenges in the Therapeutic Landscape of Leukemia", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 10, page no.b318-b332, October-2025, Available :http://www.ijrti.org/papers/IJRTI2510139.pdf |
| Downloads: | 00075 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2510139
Registration ID:207095
Published In: Volume 10 Issue 10, October-2025
DOI (Digital Object Identifier):
Page No: b318-b332 Country: Bhavnagar, Gujarat, India Research Area: Biological Science Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2510139 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2510139 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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