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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Volume 10 | Issue 5
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Impact Factor : 8.14
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| Paper Title: | Fomulation And Evaluation of Buccoadhesive Tablets of Baricitinib |
| Authors Name: | Zareena Begum , DR.S.M Shahidullah |
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| Author Reg. ID: |
IJRTI_181303
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| Published Paper Id: | IJRTI2007010 |
| Published In: | Volume 5 Issue 7, July-2020 |
| DOI: | |
| Abstract: | Buccal drug delivery has become one of the popular delivery systems due to its comparable and significant advantages over the conventional dosage form. The purpose of the present work was to prepare buccal adhesive tablets of Baricitinib Buccal drug delivery systems interact with the mucus layer covering the mucosal epithelial surface, and mucin molecules and increase the residence time of the dosage form at the site of absorption..Buccal dosage forms are advantageous in increasing the drug plasma concentrations and also therapeutic activity.This review covers the overview of oral mucosa, factors affecting bioadhesion and also various buccal dosage formsThe simplex experimental design was used to arrive at optimum ratio of carbopol 934, sodium cmc ,Na alginate ,HPMC K4which will provide desired drug release and mucoadhesion , swelling index, mucoadhesive strengthand invitro release of the prepared tablet was determined.The drug release and bioadhesion was dependent on the type and relative amounts of polymers . Dissolution of baricitinib from tablets was sustained release 93%release of baricitinib during 24h period. Baricitinib blocks the activity of certain enzymes involved in activating inflammation in the body.Baricitinib is used to reduce pain ,stiffness and swelling in adults with rheumatoid arthritis after other treatments have failed .Buccal delivery of drugs that undergo a first pass effect such as cardiovascular drugs , analgesics and peptides Buccal tablets were prepared by a direct compression method. this review covers the overview of oral mucosa, factors affecting bioadhesion.The results : the DSC , FTIR , analyses were determined .further the formulations was evaluated for in vitro studies , stability studies . |
| Keywords: | buccal, first pass effect, Bioadhesion, Buccal release, sustained release of tablets |
| Cite Article: | "Fomulation And Evaluation of Buccoadhesive Tablets of Baricitinib", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.5, Issue 7, page no.79 - 85, July-2020, Available :http://www.ijrti.org/papers/IJRTI2007010.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2007010
Registration ID:181303
Published In: Volume 5 Issue 7, July-2020
DOI (Digital Object Identifier):
Page No: 79 - 85 Country: HYDERABAD, beside street shadow, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2007010 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2007010 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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