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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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| Paper Title: | SOLUBILITY ENHANCEMENT OF POORLY SOLUBLE DRUG CARVEDILOL BY USING COMPLEXATION AND SOLID DISPERSION TECHNIQUES |
| Authors Name: | Mukesh Sharma , Ankitha A , Keerthy H.S , Dr. Shivanand Mutta , F R Sheeba |
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IJRTI_183038
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| Published Paper Id: | IJRTI2207122 |
| Published In: | Volume 7 Issue 7, July-2022 |
| DOI: | |
| Abstract: | Background and objective: The prime requirement of any drug therapy is Bioavailability. At present most of the new chemical entities have low aqueous solubility and high lipophilicity therefore enhancement of solubility has been major challenge in formulation development. Hence the work was carried out with the objective of formulating and evaluating the solid dispersion and inclusion complexes of Carvedilol with an aim to increase hydrophilicity and bioavailability of Carvedilol. Methods: Solid dispersions and inclusion complexes of Carvedilol were prepared using hydrophilic carriers PEG-6000, P188, β-CD and lactose in different ratio of 1:2, 1:4, 1:6 by fusion , solvent evaporation , kneading and co-precipitation methods. The formulations were evaluated for drug release, drug content and drug-polymer interactions by using various techniques like in-vitro dissolution, UV-Visible Spectroscopy and Fourier Transform Infrared (FTIR) Spectroscopy. Results: All the formulation showed marked increase in drug release. The solid dispersion prepared by solvent method showed better release compared to that of fusion method. The inclusion complexes prepared by kneading method showed better release than co-precipitation method. Solid dispersion of Carvedilol with P188 of ratio (1:6) showed higher drug release. The formulation which showed better release was again formulated using additional functional Excipients Lactose , which showed much better release than the before formulation. Inclusion complexes prepared by kneading method with ratio of (1:6) showed higher drug release. The formulation which showed high drug release was again formulated using functional Excipients lactose, this showed better release than the drug and hydrophilic polymer. |
| Keywords: | Carvedilol, Solid dispersion, Inclusion complexes, PEG6000, P188, β-CD, lactose, Solvent Evaporation, Kneading method, Fusion method, Co-precipitation method. |
| Cite Article: | "SOLUBILITY ENHANCEMENT OF POORLY SOLUBLE DRUG CARVEDILOL BY USING COMPLEXATION AND SOLID DISPERSION TECHNIQUES", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 7, page no.826 - 835, July-2022, Available :http://www.ijrti.org/papers/IJRTI2207122.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2207122
Registration ID:183038
Published In: Volume 7 Issue 7, July-2022
DOI (Digital Object Identifier):
Page No: 826 - 835 Country: Bangalore, Karnataka, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2207122 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2207122 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
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