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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 10
Issue Published : 109
Article Submitted : 15895
Article Published : 7024
Total Authors : 18898
Total Reviewer : 679
Total Countries : 124
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| Paper Title: | Interface analysis of DnaK-GrpE-DnaJ chaperon system of Mycobacterium tuberculosis |
| Authors Name: | Ananya Das Mahapatra |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJRTI_183088
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| Published Paper Id: | IJRTI2207231 |
| Published In: | Volume 7 Issue 7, July-2022 |
| DOI: | |
| Abstract: | The biological functions of proteins are governed by their proper folding and assembly. Protein chaperones are essential in all domains of life to prevent and resolve protein misfolding during translation and proteotoxic stress. Mycobacterium tuberculosis capsular heat shock protein DanK is a molecular chaperone. This chaperone interacts with protein substrates in an ATP-dependent manner to prevent aggregation and promote protein folding. This activity is stimulated by DnaJ and GrpE. ATP-dependent Mycobacterium DnaK (Hsp70) chaperone’s function is controlled in part by the nucleotide exchange factor (NEF) co-chaperone GrpE. Recently crystal structure of Mycobacterium tuberculosis DnaK has been deciphered but there is no three-dimensional structure of the DnaK-DnaJ and DnaK-GrpE complex reported to date. In this piece of work, we modeled the DnaJ and GrpE protein and docked with the crystal structures with DnaK. |
| Keywords: | DnaK, GrpE, DnaJ, GrpE, Chaperone, Hsp70 |
| Cite Article: | "Interface analysis of DnaK-GrpE-DnaJ chaperon system of Mycobacterium tuberculosis", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 7, page no.1470 - 1482, June-2022, Available :http://www.ijrti.org/papers/IJRTI2207231.pdf |
| Downloads: | 000204897 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2207231
Registration ID:183088
Published In: Volume 7 Issue 7, July-2022
DOI (Digital Object Identifier):
Page No: 1470 - 1482 Country: -, -, - Research Area: Engineering Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2207231 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2207231 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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