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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14

Issue per Year : 12

Volume Published : 7

Issue Published : 79

Article Submitted : 5528

Article Published : 3056

Total Authors : 7817

Total Reviewer : 540

Total Countries : 68

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Paper Title: DEVELOPMENT AND VALIDATION OF TERIZIDONE BY RP HPLC
Authors Name: Khushbu Makwana , Kartik B. Vyas , Janakkumar R. Shukla
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IJRTI_183495
Published Paper Id: IJRTI2208073
Published In: Volume 7 Issue 8, August-2022
DOI:
Abstract: Terizidone is the well-known psychoactive drug of class benzodiazepam. Terizidone is a bacteriostatic second-line agent for MDR-TB used internationally, but is not currently approved in the United States. It is a combination of two molecules of CS. The MOA includes competitively inhibiting l-alanine racemase and d-alanine ligase to inhibit cell wall synthesis. Known AEs are considered to be fewer than with CS, but still include seizures, dizziness, slurred speech, tremors, insomnia, confusion, depression, and suicidal tendencies. A simple, precise, accurate, reproducible RP-HPLC method was developed and validated for the simultaneous estimation of Terizidone in bulk and in pharmaceutical dosage forms. Chromatographic separation was carried out on a Thermo-hypersil C8 column (250mm×4.6mm i.d,5μm) utilizing a mobile phase consisting of acetonitrile and 0.01M ammonium phosphate buffer (pH adjusted to 3.0 with ortho phosphoric acid) in the ratio of 55:45 v/v at a flow rate of 1ml/min with UV detection at 242nm. The retention times of Terizidone were 2.23 min. The developed method was validated in terms of selectivity, sensitivity, accuracy, precision, linearity, specificity, limit of detection and limit of quantification. The linear range was found to be 20-82 μg/ml.
Keywords: Terizidone, Linearity, selectivity, sensitivity, Reverse Phase HPLC, validation, benzodiazepam.
Cite Article: "DEVELOPMENT AND VALIDATION OF TERIZIDONE BY RP HPLC", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 8, page no.463 - 466, August-2022, Available :http://www.ijrti.org/papers/IJRTI2208073.pdf
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ISSN: 2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publication Details: Published Paper ID: IJRTI2208073
Registration ID:183495
Published In: Volume 7 Issue 8, August-2022
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Page No: 463 - 466
Country: Gandhinagar, Gujarat, India
Research Area: Chemistry
Publisher : IJ Publication
Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2208073
Published Paper PDF: https://www.ijrti.org/papers/IJRTI2208073
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016

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