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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14

Issue per Year : 12

Volume Published : 7

Issue Published : 79

Article Submitted : 5528

Article Published : 3054

Total Authors : 7813

Total Reviewer : 540

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Paper Title: Structural and functional changes in the internal rat`s organs under the influence of a food additive complex
Authors Name: Jha Sahil Kumar , Svitlana Vladyslavivna Donchenko , Rauth Upasona
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Published Paper Id: IJRTI2208185
Published In: Volume 7 Issue 8, August-2022
Abstract: The following article brings to attention the use of various Sodium based food additives; their biochemical, morphological and in part physiological impacts on the human body (brain, cardiovascular system, kidneys), especially emphasizing the direct and indirect effects on the adrenal glands. The use of food additives as preservatives, taste enhancers and coloring agents like MSG (monosodium glutamate), sodium nitrite and Ponceau 4R (tri-sodium salt) are now studied for their detrimental health effects on humans. Most commonly faced problems with use of additives are elevated blood pressure, obesity (by interruption of the leptin-mediated signalling pathway of the hypothalamus and increasing appetite), impaired glucose tolerance and insulin resistance to peripheral glucose uptake leading to increased levels in blood consequently affecting the brain (diabetic neuropathy, vascular dementia). In the brain, prolonged elevated levels of glutamate (excitatory neurotransmitter) can overexcite metabotropic and ionotropic receptors resulting in death of nerve cells. Ponceau 4R or E124 is banned in countries like USA and Canada for its carcinogenic effects. The issue arises in the level of usage i.e. The quantity of these additives, which can cause clinical, morphological and physiological impacts on the human body, especially adrenal glands. As the endogenous nitrites are cytoprotective but excess of nitrites can lead to oxidative stress; thus leading to impaired action of the hypothalamus-pituitary-adrenal axis (in the mammalian experiment), showing stunted growth, slow or non-functional neonatal brain development; these similarities are comparable with those in humans as observed in PTSD (post-traumatic stress disorder).
Keywords: monosodium glutamate, sodium nitrite, Ponceau 4R, food additives, adrenal glands.
Cite Article: "Structural and functional changes in the internal rat`s organs under the influence of a food additive complex", International Journal of Science & Engineering Development Research (, ISSN:2455-2631, Vol.7, Issue 8, page no.1162 - 1164, August-2022, Available :
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ISSN: 2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publication Details: Published Paper ID: IJRTI2208185
Registration ID:183820
Published In: Volume 7 Issue 8, August-2022
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Page No: 1162 - 1164
Country: Delhi Cantt, Delhi, India
Research Area: Medical Science
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016

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