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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | EVALUATION OF GENOTOXICITY OF BERGENIA LIGULATA BY COMET ASSAY |
| Authors Name: | S.Malathi Varma , S.Kanchana |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJRTI_183747
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| Published Paper Id: | IJRTI2208199 |
| Published In: | Volume 7 Issue 8, August-2022 |
| DOI: | |
| Abstract: | ABSTRACT: “Bergenia ligulata” is a member of “Saxifragaceae” family. It is commonly known as Pashanabheda (pashana means stone and Bheda means break). Bergenia are of three types Bergenia ciliata, Bergenia ligulata, Bergenia stracheyi. The whole plant and rhizomes of Bergenia ligulata are used to dissolve kidney and bladder stones. Bergenia ligulata has been used as an Ayurvedic medicine from centuries. Bergenia ligulata has a primary phenolic compound called Bergenin and it also contains other phenolic chemicals. The present study was conducted to evaluate the genotoxicity of Bergenia ligulata by comet assay. Fresh leaves of Bergenia ligulata were collected and washed thoroughly and made into powder. Aqueous, Chloroform and Methanol extracts were prepared from this powder and used to find out the genotoxicity of Bergenia ligulata by comet assay method. Lymphocytes were extracted from human blood and used as a sample for testing. Comet Assay or Single cell gel electrophoresis is a method used for measuring DNA damage. By the tail length we can measure the degree of DNA damage. Both aqueous and methanol extracts at 750µg/ml and 1000μg/ml showed necrosis (Cell death) whereas the chloroform extract did not show much necrosis. Among the three extracts the aqueous and methanol extracts showed more genotoxicity than compared to chloroform extract. Results conclude the plant Bergenia ligulata was found to be genotoxic in nature. |
| Keywords: | Bergenia ligulata; genotoxicity; comet assay; Single cell gel electrophoresis ; Extracts |
| Cite Article: | "EVALUATION OF GENOTOXICITY OF BERGENIA LIGULATA BY COMET ASSAY", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 8, page no.1228 - 1242, August-2022, Available :http://www.ijrti.org/papers/IJRTI2208199.pdf |
| Downloads: | 000205297 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
| Publication Details: |
Published Paper ID: IJRTI2208199
Registration ID:183747
Published In: Volume 7 Issue 8, August-2022
DOI (Digital Object Identifier):
Page No: 1228 - 1242 Country: Hyderabad, Telangana, India Research Area: Life Sciences Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2208199 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2208199 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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