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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | NEW METHOD DEVELOPMENT AND VALIDATION OF AN RP-HPLC METHOD FOR THE DETERMINATION OF LEVOMILNACIPRAN IN BULK AND PHARMACEUTICAL DOSAGE FORM. |
| Authors Name: | KUMARI KHUSHBOO , Chandanam Sreedhar , Sreenivas Rao T , Harsha K Triphathy , Dillan Kumar |
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IJRTI_184478
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| Published Paper Id: | IJRTI2210101 |
| Published In: | Volume 7 Issue 10, October-2022 |
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| Abstract: | To establish sensitive and accurate methods for developing and validating analytical methods for estimation of levomilnacipran in bulk and pharmaceutical dosage forms. A mixture of 10 mM Dipotassium hydrogen phosphate buffer pH 6.5 and Methanol in the ratio of 50:50 (v/v%) was used as the mobile phase. A working standard solution of a concentration of 20 µg/ml was used. An XBridge™ C18 column 5µ (250 mm x 4.6 mm) was used for the analysis at a flow rate of 1 ml/min, injection volume of 20 µl, run time of 10 mins, and detection wavelength of 210 nm. The %RSD values of precision studies were found to be below the accepted limit of 2%. The method was found to be linear with a correlation coefficient (r2) of 0.998. The method was also found to be accurate and robust with suitable values. The LOD and LOQ of the method were found to be 1.42 µg/ml and 4.75 µg/ml respectively. |
| Keywords: | levomilnacipran, RP-HPLC, validation, LOD, LOQ |
| Cite Article: | "NEW METHOD DEVELOPMENT AND VALIDATION OF AN RP-HPLC METHOD FOR THE DETERMINATION OF LEVOMILNACIPRAN IN BULK AND PHARMACEUTICAL DOSAGE FORM.", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 10, page no.747 - 753, October-2022, Available :http://www.ijrti.org/papers/IJRTI2210101.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2210101
Registration ID:184478
Published In: Volume 7 Issue 10, October-2022
DOI (Digital Object Identifier):
Page No: 747 - 753 Country: Bangalore, karnataka, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2210101 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2210101 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016
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