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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 10
Issue Published : 113
Article Submitted : 18006
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Total Authors : 20484
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| Paper Title: | FORMULATION OF AMORPHOUS TERNARY SOLID DISPERSION OF POORLY SOLUBLE DRUG-DAPAGLIFLOZIN |
| Authors Name: | Amar kishor Das , Sowjanya Battu , Mythily Shivaramakrishnan , Suchutra D , B A Vishwanath |
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IJRTI_184580
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| Published Paper Id: | IJRTI2211041 |
| Published In: | Volume 7 Issue 11, November-2022 |
| DOI: | |
| Abstract: | The Formulation of solid dispersions can be easily prepared with adequate physical properties and required particle size and release characterstics which might be an advantage for the solubility enhancement. Screening design helped in identifying the significant characters such as particle size and the ratios of drugs and excipients, that affected the response variables. Solid dispersion system of Dapagliflozin used could improve the solubility and dissolution rate of Dapagliflozin. The above study demonstrated the use of PEG 4000, PVP K-30 and HPMC in combination for the formulation of solid dispersions in solubility and dissolution enhancement by kneading method. PXRD and DSC studies indicated the transformation of crystalline Dapagliflozin to amorphous form by solid dispersion technology. The aqueous solubility and dissolution study shows a remarkable improvement in solubility, where F3 was found to have the maximum solubility 2.535±0.09 mg/mL |
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| Cite Article: | "FORMULATION OF AMORPHOUS TERNARY SOLID DISPERSION OF POORLY SOLUBLE DRUG-DAPAGLIFLOZIN", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 11, page no.257 - 263, November-2022, Available :http://www.ijrti.org/papers/IJRTI2211041.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2211041
Registration ID:184580
Published In: Volume 7 Issue 11, November-2022
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Page No: 257 - 263 Country: Bangalore, Karnataka, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2211041 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2211041 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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