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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14

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Paper Title: Anti-Inflammatory And Anti-Neurodegenerative Properties Of Lauric Acid From Coconut Oil On Hippocampal And Cerebral Cortex Pyramidal Cells Of Wistar Rats With Lead Induced Neurotoxicity
Authors Name: Ezugwu, Ndubuisi Samuel , Anyanwu Emeka Godson , Christian Ejuiwa Mba
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Published Paper Id: IJRTI2211043
Published In: Volume 7 Issue 11, November-2022
Abstract: Background: The present study investigated the anti-inflammatory and anti-neurodegenerative properties of lauric acid from coconut oil on hippocampal and cerebral cortex pyramidal cells of Wistar rats with lead-induced neurotoxicity. Methodology: Fractional crystallization was used to fractionate the lauric acid from coconut oil. Thirty-five adult male wistar rats (150 – 200g) were divided into seven groups of experimental protocols: (A, B, C, D, E, F, and G). Each group had five rats. Groups A, B, C, D, E, F, and G in each of the protocols represent groups treated with: (food only), (pb2+ only), (lauric acid only), (pb2++ 500mg/kg LA), (pb2++ 1000mg/kg LA), (pb2++ 2000mg/kg LA), and (pb2++ 0.2mg/kg Donepezil) respectively. Neurotoxicity was induced by the administration of 120mg/kg of Pb2+ orally, daily for seven days. After the treatment Period, the animals were sacrificed via cervical dislocation, and blood samples were collected for neuroinflammatory, pyramidal cell, and oxidative stress assays. Perfusion was made, and the brains were harvested, rinsed in normal saline, fixed in 10% formal saline, and subjected to histological studies. Results: There was a significant decrease (p < 0.05) in CamKII, MAP-2, SOD, and CAT with a significant increase (p < 0.05) in TNF, IL-17, and MDA in the Pb2+ treated group without lauric acid intervention when compared with post-treatment with lauric acid and donepezil after Pb2+ induced toxicity. Post-treatment with lauric acid significantly (p < 0.05) normalized the biochemical parameters. This biochemical fact is supported by neurobehavioural and histopathological results. This indicates that lauric acid has the potential that may have restored the pyramidal cells. Treatment with 1000mg/kg dose lauric acid produced the most remarkable abatement. Conclusion: There were comparable degrees of abatement as evidenced by the neurobehavioural balance, normal appearance of the pyramidal cells, with conspicuous apical and basal dendrites, and no signs of degeneration. Therefore, lauric acid has justified in this study that well-protected pyramidal cells may be the indication of its anti-inflammatory and anti-neurodegenerative properties. Meanwhile, it is worthwhile to consider this aspect at a deeper level of investigation using different animal models and methods.
Keywords: Anti-inflammatory, Lauric Acid, Hippocampus, Cerebral Cortex, Pyramidal Cells
Cite Article: "Anti-Inflammatory And Anti-Neurodegenerative Properties Of Lauric Acid From Coconut Oil On Hippocampal And Cerebral Cortex Pyramidal Cells Of Wistar Rats With Lead Induced Neurotoxicity", International Journal of Science & Engineering Development Research (, ISSN:2455-2631, Vol.7, Issue 11, page no.274 - 301, November-2022, Available :
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ISSN: 2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publication Details: Published Paper ID: IJRTI2211043
Registration ID:184549
Published In: Volume 7 Issue 11, November-2022
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Page No: 274 - 301
Country: Enugu, Enugu, Nigeria
Research Area: Biological Science
Publisher : IJ Publication
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ISSN: 2456-3315
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