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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | Effect of Anticoagulant Therapy in COVID-19 Hospitalized Patients |
| Authors Name: | Ola Haidar , Firas Hussein |
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| Author Reg. ID: |
IJRTI_184678
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| Published Paper Id: | IJRTI2211078 |
| Published In: | Volume 7 Issue 11, November-2022 |
| DOI: | |
| Abstract: | INTRODUCTION: COVID-19 induces a prothrombotic state as evidenced by microvascular thrombi in the renal and pulmonary vasculature . However, limited data are available to guide the antithrombotic prophylaxis strategy OBJECTIVES: We sought to determine if empiric therapeutic anticoagulation (tAC) affected survival in COVID-19 patients compared to prophylactic anticoagulation (pAC). METHODS and MATERIALS: A retrospective cohort study was done to determine the impact of therapeutic AC in COVID-19 hospitalized patients between August 25-2020 and October 15-2020. Independent T_test was performed to calculate mean differences, and odds ratios were calculated to examine the relationship between AC dosing and clinical outcomes. RESULTS: Among 106 patients 39 were treated with therapeutic AC and 67 were treated with prophylactic AC. When comparing clinical outcomes between the two arms ; there was no statistically significant difference in in-hospital mortality (OR:1.23, 95%CI:0.5-3.1, P:0.6). As well as the upgrade to ICU/Intubation (OR:0.98, 95%CI:0.3-2.4, P:0.9), also the need to NIV (Non-invasive mechanical ventilation) was not statistically different (OR:1.06 ,95%CI:0.4-2.6, P:0.8). While major bleeding was significantly higher in the therapeutic group [ (7.7%) versus (1.5%)] (OR:0.18 ,95%CI:0.01 -1.8, P:0.01). Thrombotic events occurred in 5 patients (4.7%), and was significantly higher in the prophylactic group [(6%) versus (2.6%)] (OR:2.4 ,95%CI:1.2-12.3, P:0.04). CONCLUSION: Therapeutic AC compared to prophylactic AC did not result in a significant difference in the primary outcomes of in-hospital mortality, upgrade to ICU/Intubation , need to NIV. Our results do not support the empirical use of therapeutic dose in unselected patients. More studies are required to determine the optimal AC regimens. |
| Keywords: | Anticoagulation , Bleeding ,Coagulopathy, COVID-19, Thrombosis |
| Cite Article: | "Effect of Anticoagulant Therapy in COVID-19 Hospitalized Patients", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 11, page no.541 - 546, November-2022, Available :http://www.ijrti.org/papers/IJRTI2211078.pdf |
| Downloads: | 000205123 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2211078
Registration ID:184678
Published In: Volume 7 Issue 11, November-2022
DOI (Digital Object Identifier):
Page No: 541 - 546 Country: Lattakia, Lattakia, Syrian Arab Republic Research Area: Medical Science Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2211078 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2211078 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
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