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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | Assessing the clinical efficacy of Ursodeoxycholic acid (UDCA) as a local drug delivery agent in the treatment of intra-bony defects: a clinico-radiographic study |
| Authors Name: | Bolla Sushma , Rampalli Viswa Chandra , Naveen Anumalla , Aileni Amarender Reddy |
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IJRTI_185292
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| Published Paper Id: | IJRTI2302079 |
| Published In: | Volume 8 Issue 2, February-2023 |
| DOI: | http://doi.one/10.1729/Journal.33220 |
| Abstract: | Aim & Objectives: The purpose of this clinical trial is to evaluate periodontal outcomes after local delivery of Ursodeoxycholic acid (UDCA) gel in intra-bony defects. Patients and methods: 26 subjects participated in this study. Patients were randomly allocated into two experimental groups: the test sites received scaling and root planning (SRP) with local drug delivery of UDCA in the pocket having probing pocket depths (PPD) ≥ 5mm with intra-bony defects; whereas the control sites received SRP with placebo gel. Radiographically ImageJ® analysis was used to evaluate volume of the defect fill from baseline to 6 months. Clinical parameters included recording of probing pocket depths (PPD), clinical attachment level (CAL), gingival index (GI), bleeding index (BI) at baseline, 3 months and 6 months. Results: There was statistically no significant difference in the defect volume/fill from baseline to 6 months in the test and control groups. Significant difference was seen in reduction of PPD from baseline to 6 months; although it was not evident at 3 months. A statistically significant difference was seen in reduction of GI and BI scores with gain in CAL in the test group when compared to the control group from baseline to 3 months and 6 months. Conclusion: The present clinical trial revealed that the anti-oxidant and anti-inflammatory properties of UDCA had an additive effect on SRP by showing improvement in the periodontal clinical parameters. It can be concluded that local drug delivery of UDCA may have an additive therapeutic effects in non-surgical periodontal therapy. |
| Keywords: | Periodontitis, Ursodeoxycholic acid, Anti oxidant property, Defect volume |
| Cite Article: | "Assessing the clinical efficacy of Ursodeoxycholic acid (UDCA) as a local drug delivery agent in the treatment of intra-bony defects: a clinico-radiographic study", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 2, page no.476 - 483, February-2023, Available :http://www.ijrti.org/papers/IJRTI2302079.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2302079
Registration ID:185292
Published In: Volume 8 Issue 2, February-2023
DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.33220
Page No: 476 - 483 Country: vidhyaranyapuri, Hanamkonda, Warangal, Telangana, India Research Area: Medical Science Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2302079 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2302079 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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