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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14

Issue per Year : 12

Volume Published : 8

Issue Published : 82

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Paper Title: Biodegradable Microspheres for Captopril Drug Delivery
Authors Name: Rima Farag Elmzughi , Mokhtar M. El-Baseir
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IJRTI_185333
Published Paper Id: IJRTI2303029
Published In: Volume 8 Issue 3, March-2023
DOI:
Abstract: Abstract This paper presents formulation and evaluation of Poly (L-Lactide) microspheres for captopril delivery. Microspheres were prepared using water in oil in water (W/O/W) solvent evaporation method. The microspheres were evaluated for the yield, particle size and surface morphology using scanning electron microscopy (SEM). Entrapment efficiency and drug loading were assayed using UV-visible spectrophotometric system. In-vitro drug release was conducted in phosphate buffer (pH 7.4) and in 0.1 N HCl (pH 1.2) as dissolution medium. FTIR spectroscopy was used to study any interaction between the drug and components of the microparticles. Results showed that the method was suitable for formulating microspheres with an average particle size of 3.62 ± 0.35 µm having entrapment efficiency of captopril up to 98.74 %. SEM characterization results showed that the microspheres have spherical shape and smooth surface. Drug-polymer ratio was found to alter the microspheres yield and entrapment efficiency. FTIR study revealed the absence of any interaction between the components of the microspheres. The drug release study showed that microspheres were able to sustain the release of captopril up to 6 hrs in acidic media (pH 1.2) and up to 30 min in phosphate buffer (pH 7.4). The mechanism of drug release of captopril in phosphate buffer is suggested to be via diffusion process and to follow Korsmeyer-Peppas model. It is possible to sustain the release of captopril using poly (L-Lactide)microspheres.
Keywords: Key words: Biodegredable-Polymeric microspheres, Poly (L-Lactide), Captopril, Mechanism of drug release.
Cite Article: "Biodegradable Microspheres for Captopril Drug Delivery", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 3, page no.180 - 186, March-2023, Available :http://www.ijrti.org/papers/IJRTI2303029.pdf
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ISSN: 2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publication Details: Published Paper ID: IJRTI2303029
Registration ID:185333
Published In: Volume 8 Issue 3, March-2023
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Page No: 180 - 186
Country: Tripoli, Tripoli, Libyan Arab Jamahiriya
Research Area: Pharmacy
Publisher : IJ Publication
Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2303029
Published Paper PDF: https://www.ijrti.org/papers/IJRTI2303029
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016

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